Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Shubhanchi Nigam, Benjamin P. Burke, Laura H. Davies, Juozas Domarkas, Jennifer F. Wallis, Paul G. Waddell, Jennifer S. Waby, David M. Benoit, Anne Marie Seymour, Christopher Cawthorne, Lee J. Higham*, Stephen J. Archibald

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Original languageEnglish
Pages (from-to)7114-7117
Number of pages4
JournalChemical Communications
Volume52
Issue number44
DOIs
Publication statusPublished - 2016

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