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Structure and substrate specificity of acetyltransferase ACIAD1637 from Acinetobacter baylyi ADP1

Research output: Contribution to journalArticle

Anna Marie Davies, Renee Tata, Alison Snape, Brian J. Sutton, Paul R. Brown

Original languageEnglish
Pages (from-to)484 - 489
JournalBiochimie
Volume91
Issue number4
DOIs
Publication statusPublished - Apr 2009

King's Authors

Abstract

Gene ACIAD1637 from Acinetobacter baylyi ADP1 encodes a 182 amino acid putative antibiotic resistance protein. The structure of this protein (termed acepita) has been solved in space group P-2 to 2.35 angstrom resolution. Acepita belongs to the GCN5-related N-acetyltransferase (GNAT) family, and contains the four sequence motifs conserved among family members. The structure of acepita is compared with that of pita, its homologue from Pseudomonas aeruginosa. Acepita has a similar substrate profile to pita and performs a similar function.

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