Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

Richard A. Campbell; Yussif Saaka; Yanan Shao; Yuri Gerelli; Robert Cubitt; Ewa Nazaruk; Dorota Matyszewska; M. Jayne Lawrence

doi:10.1016/j.jcis.2018.07.022

Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

Richard A. Campbell, Yussif Saaka, Yanan Shao, Yuri Gerelli, Robert Cubitt, Ewa Nazaruk, Dorota Matyszewska, M. Jayne Lawrence

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

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Abstract

Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfactant and phospholipid monolayers at the air/water interface has not yet been established. To address this shortcoming, first a systematic evaluation of the suitability of different models is presented. The result is a comprehensive validation of an optimum model, which is evidently much needed in the field, and which we recommend as a starting point for future data treatment. While its limitations are openly discussed, consequences of failing to take into account various key aspects are critically examined and the systematic errors quantified. On the basis of this physical framework, we go on to show for the first time that neutron reflectometry can be used to quantify directly in situ at the air/water interface the extent of acyl chain compaction of phospholipid monolayers with respect to their phase. The achieved precision of this novel quantification is ∼10%. These advances together enhance significantly the potential for exploitation in future studies data from a broad range of systems including those involving synthetic polymers, proteins, DNA, nanoparticles and drugs.

Original language	English
Pages (from-to)	98-108
Journal	JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume	531
Early online date	7 Jul 2018
DOIs	https://doi.org/10.1016/j.jcis.2018.07.022
Publication status	Published - 1 Dec 2018

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10.1016/j.jcis.2018.07.022

Structure of Surfactant_CAMPBELL_Accepted 6Jul2018_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 1.86 MBLicence: CC BY-NC-ND

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title = "Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data",

abstract = "Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfactant and phospholipid monolayers at the air/water interface has not yet been established. To address this shortcoming, first a systematic evaluation of the suitability of different models is presented. The result is a comprehensive validation of an optimum model, which is evidently much needed in the field, and which we recommend as a starting point for future data treatment. While its limitations are openly discussed, consequences of failing to take into account various key aspects are critically examined and the systematic errors quantified. On the basis of this physical framework, we go on to show for the first time that neutron reflectometry can be used to quantify directly in situ at the air/water interface the extent of acyl chain compaction of phospholipid monolayers with respect to their phase. The achieved precision of this novel quantification is ∼10%. These advances together enhance significantly the potential for exploitation in future studies data from a broad range of systems including those involving synthetic polymers, proteins, DNA, nanoparticles and drugs.",

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T1 - Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

AU - Campbell, Richard A.

AU - Saaka, Yussif

AU - Shao, Yanan

AU - Gerelli, Yuri

AU - Cubitt, Robert

AU - Nazaruk, Ewa

AU - Matyszewska, Dorota

AU - Jayne Lawrence, M.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfactant and phospholipid monolayers at the air/water interface has not yet been established. To address this shortcoming, first a systematic evaluation of the suitability of different models is presented. The result is a comprehensive validation of an optimum model, which is evidently much needed in the field, and which we recommend as a starting point for future data treatment. While its limitations are openly discussed, consequences of failing to take into account various key aspects are critically examined and the systematic errors quantified. On the basis of this physical framework, we go on to show for the first time that neutron reflectometry can be used to quantify directly in situ at the air/water interface the extent of acyl chain compaction of phospholipid monolayers with respect to their phase. The achieved precision of this novel quantification is ∼10%. These advances together enhance significantly the potential for exploitation in future studies data from a broad range of systems including those involving synthetic polymers, proteins, DNA, nanoparticles and drugs.

AB - Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfactant and phospholipid monolayers at the air/water interface has not yet been established. To address this shortcoming, first a systematic evaluation of the suitability of different models is presented. The result is a comprehensive validation of an optimum model, which is evidently much needed in the field, and which we recommend as a starting point for future data treatment. While its limitations are openly discussed, consequences of failing to take into account various key aspects are critically examined and the systematic errors quantified. On the basis of this physical framework, we go on to show for the first time that neutron reflectometry can be used to quantify directly in situ at the air/water interface the extent of acyl chain compaction of phospholipid monolayers with respect to their phase. The achieved precision of this novel quantification is ∼10%. These advances together enhance significantly the potential for exploitation in future studies data from a broad range of systems including those involving synthetic polymers, proteins, DNA, nanoparticles and drugs.

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DO - 10.1016/j.jcis.2018.07.022

M3 - Article

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JO - JOURNAL OF COLLOID AND INTERFACE SCIENCE

JF - JOURNAL OF COLLOID AND INTERFACE SCIENCE

ER -

Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

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