Studies of model biological and bio-mimetic membrane structure: Reflectivity vs diffraction, a critical comparison

F. Foglia, M. J. Lawrence, D. J. Barlow*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Recent years have seen very significant progress made in the application of X-ray and neutron diffraction and reflectivity in structural studies of lipid and lipid-protein membranes. Improvements in instrumentation and the development of new sample preparation techniques and specialized sample environments have afforded data that provide a greater resolution of structural detail, and in many cases on systems that have a complexity of composition and architecture that closely mimic those of true biological membranes. This review provides an overview of the various methodologies involved in membrane reflectivity and diffraction experiments, with a primary focus on aspects of sample preparation and data analysis. We then provide a review of some of the research performed in this area over the period 2010-2015, offering a critical comparison of reflectivity vs. diffraction experiments.

Original languageEnglish
Pages (from-to)235-243
Number of pages9
JournalCURRENT OPINION IN COLLOID AND INTERFACE SCIENCE
Volume20
Issue number4
DOIs
Publication statusPublished - 1 Aug 2015

Keywords

  • Membranes
  • Neutron diffraction
  • Neutron reflectivity
  • X-ray diffraction
  • X-ray reflectivity

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