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Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine

Research output: Contribution to journalArticle

S Banerjee, J Hellier, R Romeo, M Dewey, M Knapp, C Ballard, R Baldwin, P Bentham, C Fox, C Holmes, C Katona, C Lawton, J Lindesay, G Livingston, Niall McCrae, E Moniz-Cook, J Murray, S Nurock, M Orrell, J O'Brien & 5 more M Poppe, A Thomas, R Walwyn, K Wilson, A Burns

Original languageEnglish
Pages (from-to)1-166
Number of pages166
JournalHealth technology assessment (Winchester, England)
Issue number7
PublishedFeb 2013

King's Authors


Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.

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