Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine

S Banerjee; J Hellier; R Romeo; M Dewey; M Knapp; C Ballard; R Baldwin; P Bentham; C Fox; C Holmes; C Katona; C Lawton; J Lindesay; G Livingston; Niall McCrae; E Moniz-Cook; J Murray; S Nurock; M Orrell; J O'Brien; M Poppe; A Thomas; R Walwyn; K Wilson; A Burns

doi:10.3310/hta17070

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine

S Banerjee, J Hellier, R Romeo, M Dewey, M Knapp, C Ballard, R Baldwin, P Bentham, C Fox, C Holmes, C Katona, C Lawton, J Lindesay, G Livingston, Niall McCrae, E Moniz-Cook, J Murray, S Nurock, M Orrell, J O'BrienM Poppe, A Thomas, R Walwyn, K Wilson, A Burns

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.

Original language	English
Pages (from-to)	1-166
Number of pages	166
Journal	Health technology assessment (Winchester, England)
Volume	17
Issue number	7
DOIs	https://doi.org/10.3310/hta17070
Publication status	Published - Feb 2013

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Banerjee, S., Hellier, J., Romeo, R., Dewey, M., Knapp, M., Ballard, C., Baldwin, R., Bentham, P., Fox, C., Holmes, C., Katona, C., Lawton, C., Lindesay, J., Livingston, G., McCrae, N., Moniz-Cook, E., Murray, J., Nurock, S., Orrell, M., ... Burns, A. (2013). Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. Health technology assessment (Winchester, England), 17(7), 1-166. https://doi.org/10.3310/hta17070

Banerjee, S ; Hellier, J ; Romeo, R et al. / Study of the use of antidepressants for depression in dementia : the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. In: Health technology assessment (Winchester, England). 2013 ; Vol. 17, No. 7. pp. 1-166.

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abstract = "Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.",

author = "S Banerjee and J Hellier and R Romeo and M Dewey and M Knapp and C Ballard and R Baldwin and P Bentham and C Fox and C Holmes and C Katona and C Lawton and J Lindesay and G Livingston and Niall McCrae and E Moniz-Cook and J Murray and S Nurock and M Orrell and J O'Brien and M Poppe and A Thomas and R Walwyn and K Wilson and A Burns",

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Banerjee, S , Hellier, J , Romeo, R , Dewey, M , Knapp, M , Ballard, C, Baldwin, R, Bentham, P, Fox, C, Holmes, C, Katona, C, Lawton, C, Lindesay, J, Livingston, G, McCrae, N, Moniz-Cook, E, Murray, J, Nurock, S, Orrell, M, O'Brien, J, Poppe, M, Thomas, A, Walwyn, R, Wilson, K & Burns, A 2013, 'Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine', Health technology assessment (Winchester, England), vol. 17, no. 7, pp. 1-166. https://doi.org/10.3310/hta17070

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. / Banerjee, S ; Hellier, J ; Romeo, R et al.
In: Health technology assessment (Winchester, England), Vol. 17, No. 7, 02.2013, p. 1-166.

Research output: Contribution to journal › Article › peer-review

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T1 - Study of the use of antidepressants for depression in dementia

T2 - the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine

AU - Banerjee, S

AU - Hellier, J

AU - Romeo, R

AU - Dewey, M

AU - Knapp, M

AU - Ballard, C

AU - Baldwin, R

AU - Bentham, P

AU - Fox, C

AU - Holmes, C

AU - Katona, C

AU - Lawton, C

AU - Lindesay, J

AU - Livingston, G

AU - McCrae, Niall

AU - Moniz-Cook, E

AU - Murray, J

AU - Nurock, S

AU - Orrell, M

AU - O'Brien, J

AU - Poppe, M

AU - Thomas, A

AU - Walwyn, R

AU - Wilson, K

AU - Burns, A

PY - 2013/2

Y1 - 2013/2

N2 - Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.

AB - Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.

U2 - 10.3310/hta17070

DO - 10.3310/hta17070

M3 - Article

C2 - 23438937

SN - 2046-4924

VL - 17

SP - 1

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JO - Health technology assessment (Winchester, England)

JF - Health technology assessment (Winchester, England)

IS - 7

ER -

Banerjee S , Hellier J , Romeo R , Dewey M , Knapp M , Ballard C et al. Study of the use of antidepressants for depression in dementia: the HTA-SADD trial - a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. Health technology assessment (Winchester, England). 2013 Feb;17(7):1-166. doi: 10.3310/hta17070