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Study Protocol for The Antidepressant Advisor (ADeSS): A Decision Support System for Antidepressant Treatment for Depression in UK primary care - a feasibility study: The Antidepressant Advisor

Research output: Contribution to journalArticle

Original languageEnglish
Number of pages22
JournalBMJ Open
Publication statusAccepted/In press - 3 Apr 2020


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    Revised_Manuscript.pdf, 343 KB, application/pdf


    Accepted author manuscript

King's Authors


Introduction: The Antidepressant Advisor Study is a feasibility trial of a computerised decision-support tool which uses an algorithm to provide antidepressant treatment guidance for General Practitioners (GPs) in the UK primary care service. The tool is the first in the UK to implement national guidelines on antidepressant treatment guidance into a computerised decision support tool.
Methods and analysis: The study is a parallel group, cluster-randomised controlled feasibility trial where participants are blind to treatment allocation. GPs were assigned to two treatment arms: 1) treatment as usual, 2) computerised decision support tool to assist with antidepressant choices. The study will assess recruitment and lost to follow-up rates, GP satisfaction with the tool, and impact on health service use. A meaningful long-term roll-out unit cost will be calculated for the tool and service use data will be collected at baseline and follow-up to inform a full economic evaluation of a future trial.
Ethics and dissemination: The study has received NHS ethical approval from the London - Camberwell St Giles Research Ethics Committee (ref:17/LO/2074). The trial was pre-registered in the Clinical registry. The results of the study will be published in a pre-publication archive within one year of completion of the last follow-up assessment.

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