Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study

Vincenzo Malafarina; Francisco Uriz-Otano; Lucía Gil-Guerrero; Raquel Iniesta; Angeles Zulet; J. Alfredo Martinez

doi:10.1016/j.maturitas.2013.06.016

Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D₃ and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study

Vincenzo Malafarina^*, Francisco Uriz-Otano, Lucía Gil-Guerrero, Raquel Iniesta, Angeles Zulet, J. Alfredo Martinez

^*Corresponding author for this work

Biostatistics & Health Informatics

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Introduction: Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. Methods: A prospective randomized clinical trial among patients who have undergone an operation for a traumatic hip fracture and who are aged 65 or above will be implemented. We shall compare a control diet against a high-protein diet enriched with β-hydroxy-βmethylbutirate, calcium and vitamin D. The diet will be administered during 30 days of hospitalization in the orthopaedic geriatric rehabilitation unit. There will be 50 patients in each arm of the study. The main objective is to assess whether the experimental diet, together with rehabilitation, improves functional recovery, measured on the Barthel index. Secondary objectives are to assess changes in body composition and the prevalence of sarcopenia, obesity and mortality one year after the hip fracture. We shall also assess whether there is a relationship between specific inflammatory markers, sarcopenia and functional recovery. Conclusions: Ageing is accompanied by changes in body composition that increase the risk of falls and progressive functional loss. These factors are a public health problem because they are highly associated with disability in older people. The present study seeks to gain knowledge of those factors that are most often associated with the onset of disability and those that can be modified through diet.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Maturitas
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/j.maturitas.2013.06.016
Publication status	Published - 1 Jan 2013

Keywords

High protein
Hip fracture
Obesity
Older people
Sarcopenia
β-Hydroxy-β-methylbutirate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Malafarina, V., Uriz-Otano, F., Gil-Guerrero, L., Iniesta, R., Zulet, A., & Alfredo Martinez, J. (2013). Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D₃ and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study. Maturitas, 76(2), 123-128. https://doi.org/10.1016/j.maturitas.2013.06.016

@article{1d1f713ff543410285a2c11cd4194e89,

title = "Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study",

abstract = "Introduction: Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. Methods: A prospective randomized clinical trial among patients who have undergone an operation for a traumatic hip fracture and who are aged 65 or above will be implemented. We shall compare a control diet against a high-protein diet enriched with β-hydroxy-βmethylbutirate, calcium and vitamin D. The diet will be administered during 30 days of hospitalization in the orthopaedic geriatric rehabilitation unit. There will be 50 patients in each arm of the study. The main objective is to assess whether the experimental diet, together with rehabilitation, improves functional recovery, measured on the Barthel index. Secondary objectives are to assess changes in body composition and the prevalence of sarcopenia, obesity and mortality one year after the hip fracture. We shall also assess whether there is a relationship between specific inflammatory markers, sarcopenia and functional recovery. Conclusions: Ageing is accompanied by changes in body composition that increase the risk of falls and progressive functional loss. These factors are a public health problem because they are highly associated with disability in older people. The present study seeks to gain knowledge of those factors that are most often associated with the onset of disability and those that can be modified through diet.",

keywords = "High protein, Hip fracture, Obesity, Older people, Sarcopenia, β-Hydroxy-β-methylbutirate",

author = "Vincenzo Malafarina and Francisco Uriz-Otano and Luc{\'i}a Gil-Guerrero and Raquel Iniesta and Angeles Zulet and {Alfredo Martinez}, J.",

year = "2013",

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Malafarina, V, Uriz-Otano, F, Gil-Guerrero, L, Iniesta, R, Zulet, A & Alfredo Martinez, J 2013, 'Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D₃ and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study', Maturitas, vol. 76, no. 2, pp. 123-128. https://doi.org/10.1016/j.maturitas.2013.06.016

Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D₃ and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study. / Malafarina, Vincenzo; Uriz-Otano, Francisco; Gil-Guerrero, Lucía et al.
In: Maturitas, Vol. 76, No. 2, 01.01.2013, p. 123-128.

Research output: Contribution to journal › Article › peer-review

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T1 - Study protocol

T2 - High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. the HIPERPROT-GER study

AU - Malafarina, Vincenzo

AU - Uriz-Otano, Francisco

AU - Gil-Guerrero, Lucía

AU - Iniesta, Raquel

AU - Zulet, Angeles

AU - Alfredo Martinez, J.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Introduction: Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. Methods: A prospective randomized clinical trial among patients who have undergone an operation for a traumatic hip fracture and who are aged 65 or above will be implemented. We shall compare a control diet against a high-protein diet enriched with β-hydroxy-βmethylbutirate, calcium and vitamin D. The diet will be administered during 30 days of hospitalization in the orthopaedic geriatric rehabilitation unit. There will be 50 patients in each arm of the study. The main objective is to assess whether the experimental diet, together with rehabilitation, improves functional recovery, measured on the Barthel index. Secondary objectives are to assess changes in body composition and the prevalence of sarcopenia, obesity and mortality one year after the hip fracture. We shall also assess whether there is a relationship between specific inflammatory markers, sarcopenia and functional recovery. Conclusions: Ageing is accompanied by changes in body composition that increase the risk of falls and progressive functional loss. These factors are a public health problem because they are highly associated with disability in older people. The present study seeks to gain knowledge of those factors that are most often associated with the onset of disability and those that can be modified through diet.

AB - Introduction: Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. Methods: A prospective randomized clinical trial among patients who have undergone an operation for a traumatic hip fracture and who are aged 65 or above will be implemented. We shall compare a control diet against a high-protein diet enriched with β-hydroxy-βmethylbutirate, calcium and vitamin D. The diet will be administered during 30 days of hospitalization in the orthopaedic geriatric rehabilitation unit. There will be 50 patients in each arm of the study. The main objective is to assess whether the experimental diet, together with rehabilitation, improves functional recovery, measured on the Barthel index. Secondary objectives are to assess changes in body composition and the prevalence of sarcopenia, obesity and mortality one year after the hip fracture. We shall also assess whether there is a relationship between specific inflammatory markers, sarcopenia and functional recovery. Conclusions: Ageing is accompanied by changes in body composition that increase the risk of falls and progressive functional loss. These factors are a public health problem because they are highly associated with disability in older people. The present study seeks to gain knowledge of those factors that are most often associated with the onset of disability and those that can be modified through diet.

KW - High protein

KW - Hip fracture

KW - Obesity

KW - Older people

KW - Sarcopenia

KW - β-Hydroxy-β-methylbutirate

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DO - 10.1016/j.maturitas.2013.06.016

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