Research output: Contribution to journal › Article › peer-review
Fanni Krajner, Laila Hadaya, Grant McQueen, Kyra-Verena Sendt, Amy Gillespie, Alessia Avila, John Lally, Milly Hedges, Kelly Diederen, Oliver Howes, Gareth Barker, David Lythgoe, Matthew Kempton, Philip McGuire, James Maccabe, Alice Egerton
Original language | English |
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Article number | 13 |
Journal | NPJ SCHIZOPHRENIA |
Volume | 8 |
Issue number | 1 |
Early online date | 2 Mar 2022 |
DOIs | |
E-pub ahead of print | 2 Mar 2022 |
Published | 2 Mar 2022 |
Additional links |
The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical thickness and investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data were acquired in 24 patients with treatment-resistant schizophrenia before and 12 weeks after switching to clozapine. During clozapine treatment we observed reductions in caudate and putamen volume, lateral ventricle enlargement (P < 0.001), and reductions in thickness of the left inferior temporal cortex, left caudal middle frontal cortex, and the right temporal pole. Reductions in right caudate volume were associated with local reductions in NAA (P = 0.002). None of the morphometric changes were associated with changes in glutamate levels. These results indicate that clozapine treatment is associated with subcortical volume loss and cortical thinning and that at least some of these effects are linked to changes in neuronal or metabolic integrity.
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