Subdivision of the lateral plate mesoderm and specification of the forelimb and hindlimb forming domains

TY - JOUR

T1 - Subdivision of the lateral plate mesoderm and specification of the forelimb and hindlimb forming domains

AU - Nishimoto, Satoko

AU - Logan, Malcolm P O

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The limbs are a significant evolutionary innovation that enabled vertebrates to diversify and colonise new environments. Tetrapods have two pairs of limbs, forelimbs in the upper body and hindlimbs in the lower body. The morphologies of the forelimbs and hindlimbs are distinct, reflecting their specific locomotory functions although they share many common signalling networks that regulate their development. The paired appendages in vertebrates form at fixed positions along the rostral-caudal axis and this occurs as a consequence of earlier subdivision of the lateral plate mesoderm (LPM) into regions with distinct limb forming potential. In this review, we discuss the molecular mechanisms that confer a broad region of the flank with limb-forming potential and its subsequent refinement into distinct forelimb-forming, hindlimb-forming and interlimb territories.

AB - The limbs are a significant evolutionary innovation that enabled vertebrates to diversify and colonise new environments. Tetrapods have two pairs of limbs, forelimbs in the upper body and hindlimbs in the lower body. The morphologies of the forelimbs and hindlimbs are distinct, reflecting their specific locomotory functions although they share many common signalling networks that regulate their development. The paired appendages in vertebrates form at fixed positions along the rostral-caudal axis and this occurs as a consequence of earlier subdivision of the lateral plate mesoderm (LPM) into regions with distinct limb forming potential. In this review, we discuss the molecular mechanisms that confer a broad region of the flank with limb-forming potential and its subsequent refinement into distinct forelimb-forming, hindlimb-forming and interlimb territories.

KW - Hox genes

KW - Lateral plate mesoderm

KW - Limb development

KW - Pitx1

KW - Regionalization

KW - Tbx genes

UR - http://www.scopus.com/inward/record.url?scp=84958118411&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2015.11.011

DO - 10.1016/j.semcdb.2015.11.011

M3 - Article

AN - SCOPUS:84958118411

SN - 1084-9521

VL - 49

SP - 102

EP - 108

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -