Subepithelial dendritic B cells in orofacial granulomatosis

Pritash Patel; Francesca Barone; Carlo Nunes; Laurent Boursier; Edward Odell; Michael Escudier; Stephen Challacombe; Jonathan Brostoff; Jo Spencer; Jeremy Sanderson

doi:10.1002/ibd.21169

Subepithelial dendritic B cells in orofacial granulomatosis

Pritash Patel, Francesca Barone, Carlo Nunes, Laurent Boursier, Edward Odell, Michael Escudier, Stephen Challacombe, Jonathan Brostoff, Jo Spencer, Jeremy Sanderson

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Orofacial granulomatosis (OFG) is a chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. The pathogenesis is unknown, but it has been linked previously to Crohn's disease (CD) and more recently to dietary sensitivity. The oral mucosa is an immunologically responsive site associated with the generation of protective mucosal and systemic immune responses to vaccination and also hyperresponsiveness to allergens in some individuals. Classically, immune responses in oral mucosa are considered to be mediated by mucosa-associated lymphoid tissues (MALT), secondary lymphoid follicles that are intimately associated with epithelia.

Original language	English
Pages (from-to)	1051-1060
Number of pages	10
Journal	Inflammatory Bowel Diseases
Volume	16
Issue number	6
Early online date	18 Nov 2009
DOIs	https://doi.org/10.1002/ibd.21169
Publication status	Published - Jun 2010

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title = "Subepithelial dendritic B cells in orofacial granulomatosis",

abstract = "Orofacial granulomatosis (OFG) is a chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. The pathogenesis is unknown, but it has been linked previously to Crohn's disease (CD) and more recently to dietary sensitivity. The oral mucosa is an immunologically responsive site associated with the generation of protective mucosal and systemic immune responses to vaccination and also hyperresponsiveness to allergens in some individuals. Classically, immune responses in oral mucosa are considered to be mediated by mucosa-associated lymphoid tissues (MALT), secondary lymphoid follicles that are intimately associated with epithelia.",

author = "Pritash Patel and Francesca Barone and Carlo Nunes and Laurent Boursier and Edward Odell and Michael Escudier and Stephen Challacombe and Jonathan Brostoff and Jo Spencer and Jeremy Sanderson",

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AU - Patel, Pritash

AU - Barone, Francesca

AU - Nunes, Carlo

AU - Boursier, Laurent

AU - Odell, Edward

AU - Escudier, Michael

AU - Challacombe, Stephen

AU - Brostoff, Jonathan

AU - Spencer, Jo

AU - Sanderson, Jeremy

PY - 2010/6

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AB - Orofacial granulomatosis (OFG) is a chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. The pathogenesis is unknown, but it has been linked previously to Crohn's disease (CD) and more recently to dietary sensitivity. The oral mucosa is an immunologically responsive site associated with the generation of protective mucosal and systemic immune responses to vaccination and also hyperresponsiveness to allergens in some individuals. Classically, immune responses in oral mucosa are considered to be mediated by mucosa-associated lymphoid tissues (MALT), secondary lymphoid follicles that are intimately associated with epithelia.

U2 - 10.1002/ibd.21169

DO - 10.1002/ibd.21169

M3 - Article

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EP - 1060

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 6

ER -

Subepithelial dendritic B cells in orofacial granulomatosis

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