22 Citations (Scopus)

Abstract

Orofacial granulomatosis (OFG) is a chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. The pathogenesis is unknown, but it has been linked previously to Crohn's disease (CD) and more recently to dietary sensitivity. The oral mucosa is an immunologically responsive site associated with the generation of protective mucosal and systemic immune responses to vaccination and also hyperresponsiveness to allergens in some individuals. Classically, immune responses in oral mucosa are considered to be mediated by mucosa-associated lymphoid tissues (MALT), secondary lymphoid follicles that are intimately associated with epithelia.
Original languageEnglish
Pages (from-to)1051-1060
Number of pages10
JournalInflammatory Bowel Diseases
Volume16
Issue number6
Early online date18 Nov 2009
DOIs
Publication statusPublished - Jun 2010

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