Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A case-control study on deciduous teeth

TY - JOUR

T1 - Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A case-control study on deciduous teeth

AU - Vocale, C.

AU - Montevecchi, M.

AU - D’Alessandro, G.

AU - Gatto, M.

AU - Piana, G.

AU - Nibali, L.

AU - Re, M. C.

AU - Sambri, V.

N1 - Funding Information: The authors declare that there are no con?icts of interest and sources of funding with respect to the authorship and/or publication of this article. Publisher Copyright: © 2021. European Journal of Paediatric Dentistry. All Rights Reserved.

PY - 2021/12

Y1 - 2021/12

N2 - Down syndrome is the most common form of aneuploidia compatible with a long survival. The affected subjects are more susceptible to severe early-onset periodontal disease and show a lower risk to develop dental caries than the non-affected population. This study investigated the prevalence of periodontal pathogens in the subgingival plaque of deciduous teeth in children with Down syndrome without signs of periodontal breakdown. Thirty children suffering from Down syndrome and 46 matched healthy subjects were studied. A total of 228 subgingival plaque samples from deciduous teeth were separately collected and evaluated by polymerase chain reaction assays. In absence of periodontal impairment, Down syndrome children display a clear presence of periodontal pathogens already in the deciduous dentition. The hypothesis of an intrinsic predisposing condition is here supported.

AB - Down syndrome is the most common form of aneuploidia compatible with a long survival. The affected subjects are more susceptible to severe early-onset periodontal disease and show a lower risk to develop dental caries than the non-affected population. This study investigated the prevalence of periodontal pathogens in the subgingival plaque of deciduous teeth in children with Down syndrome without signs of periodontal breakdown. Thirty children suffering from Down syndrome and 46 matched healthy subjects were studied. A total of 228 subgingival plaque samples from deciduous teeth were separately collected and evaluated by polymerase chain reaction assays. In absence of periodontal impairment, Down syndrome children display a clear presence of periodontal pathogens already in the deciduous dentition. The hypothesis of an intrinsic predisposing condition is here supported.

KW - Child

KW - Deciduous

KW - Down syndrome

KW - Microbiology

KW - Periodontal diseases

KW - Tooth

UR - http://www.scopus.com/inward/record.url?scp=85122462915&partnerID=8YFLogxK

U2 - 10.23804/ejpd.2021.22.04.9

DO - 10.23804/ejpd.2021.22.04.9

M3 - Article

AN - SCOPUS:85122462915

SN - 1591-996X

VL - 22

SP - 309

EP - 313

JO - EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY

JF - EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY

IS - 4

ER -