Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo

Samuel J. Barnes, Rosanna P. Sammons, R. Irene Jacobsen, Jennifer Mackie, Georg B. Keller, Tara Keck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)
214 Downloads (Pure)

Abstract

Homeostatic regulation has been shown to restore cortical activity invivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.

Original languageEnglish
Pages (from-to)1290-1303
Number of pages14
JournalNeuron
Volume86
Issue number5
DOIs
Publication statusPublished - 3 Jun 2015

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