Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo

TY - JOUR

T1 - Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo

AU - Barnes, Samuel J.

AU - Sammons, Rosanna P.

AU - Jacobsen, R. Irene

AU - Mackie, Jennifer

AU - Keller, Georg B.

AU - Keck, Tara

PY - 2015/6/3

Y1 - 2015/6/3

N2 - Homeostatic regulation has been shown to restore cortical activity invivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.

AB - Homeostatic regulation has been shown to restore cortical activity invivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.

UR - http://www.scopus.com/inward/record.url?scp=84930535912&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2015.05.010

DO - 10.1016/j.neuron.2015.05.010

M3 - Article

C2 - 26050045

AN - SCOPUS:84930535912

SN - 0896-6273

VL - 86

SP - 1290

EP - 1303

JO - Neuron

JF - Neuron

IS - 5

ER -