Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Hélène Vulser; Hervé Lemaitre; Eric Artiges; Ruben Miranda; Jani Penttilä; Maren Struve; Tahmine Fadai; Viola Kappel; Yvonne Grimmer; Robert Goodman; Argyris Stringaris; Luise Poustka; Patricia Conrod; Vincent Frouin; Tobias Banaschewski; Gareth J Barker; Arun L W Bokde; Uli Bromberg; Christian Büchel; Herta Flor; Juergen Gallinat; Hugh Garavan; Penny Gowland; Andreas Heinz; Bernd Ittermann; Claire Lawrence; Eva Loth; Karl Mann; Frauke Nees; Tomas Paus; Zdenka Pausova; Marcella Rietschel; Trevor W Robbins; Michael N Smolka; Gunter Schumann; Jean-Luc Martinot; Marie-Laure Paillère-Martinot; IMAGEN Consortium (www.imagen-europe.com)

doi:10.1016/j.jaac.2015.07.006

Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Hélène Vulser, Hervé Lemaitre, Eric Artiges, Ruben Miranda, Jani Penttilä, Maren Struve, Tahmine Fadai, Viola Kappel, Yvonne Grimmer, Robert Goodman, Argyris Stringaris, Luise Poustka, Patricia Conrod, Vincent Frouin, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Uli Bromberg, Christian Büchel, Herta FlorJuergen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Claire Lawrence, Eva Loth, Karl Mann, Frauke Nees, Tomas Paus, Zdenka Pausova, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Gunter Schumann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, IMAGEN Consortium (www.imagen-europe.com)

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE: Neuroimaging findings have been reported in regions of the brain associated with emotion in both adults and adolescents with depression, but few studies have investigated whether such brain alterations can be detected in adolescents with subthreshold depression, a condition at risk for major depressive disorder. In this study, we searched for differences in brain structure at age 14 years in adolescents with subthreshold depression and their relation to depression at age 16 years.

METHOD: High-resolution structural magnetic resonance imaging was used to assess adolescents with self-reported subthreshold depression (n = 119) and healthy control adolescents (n = 461), all recruited from a community-based sample. Regional gray and white matter volumes were compared across groups using whole-brain voxel-based morphometry. The relationship between subthreshold depression at baseline and depression outcome was explored using causal mediation analyses to search for mediating effects of regional brain volumes.

RESULTS: Adolescents with subthreshold depression had smaller gray matter volume in the ventromedial prefrontal and rostral anterior cingulate cortices and caudates, and smaller white matter volumes in the anterior limb of internal capsules, left forceps minor, and right cingulum. In girls, but not in boys, the relation between subthreshold depression at baseline and high depression score at follow-up was mediated by medial-prefrontal gray matter volume.

CONCLUSION: Subthreshold depression in early adolescence might be associated with smaller gray and white matter volumes in regions of the frontal-striatal-limbic affective circuit, and the occurrence of depression in girls with subthreshold depression might be influenced by medial-prefrontal gray matter volume. However, these findings should be interpreted with caution because of the limitations of the clinical assessment methods.

Original language	English
Pages (from-to)	832-40
Number of pages	9
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	54
Issue number	10
DOIs	https://doi.org/10.1016/j.jaac.2015.07.006
Publication status	Published - Oct 2015

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Vulser, H., Lemaitre, H., Artiges, E., Miranda, R., Penttilä, J., Struve, M., Fadai, T., Kappel, V., Grimmer, Y., Goodman, R., Stringaris, A., Poustka, L., Conrod, P., Frouin, V., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., ... IMAGEN Consortium (www.imagen-europe.com) (2015). Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 54(10), 832-40. https://doi.org/10.1016/j.jaac.2015.07.006

@article{861b12c470a844088da05a890fa2e95f,

title = "Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents",

abstract = "OBJECTIVE: Neuroimaging findings have been reported in regions of the brain associated with emotion in both adults and adolescents with depression, but few studies have investigated whether such brain alterations can be detected in adolescents with subthreshold depression, a condition at risk for major depressive disorder. In this study, we searched for differences in brain structure at age 14 years in adolescents with subthreshold depression and their relation to depression at age 16 years.METHOD: High-resolution structural magnetic resonance imaging was used to assess adolescents with self-reported subthreshold depression (n = 119) and healthy control adolescents (n = 461), all recruited from a community-based sample. Regional gray and white matter volumes were compared across groups using whole-brain voxel-based morphometry. The relationship between subthreshold depression at baseline and depression outcome was explored using causal mediation analyses to search for mediating effects of regional brain volumes.RESULTS: Adolescents with subthreshold depression had smaller gray matter volume in the ventromedial prefrontal and rostral anterior cingulate cortices and caudates, and smaller white matter volumes in the anterior limb of internal capsules, left forceps minor, and right cingulum. In girls, but not in boys, the relation between subthreshold depression at baseline and high depression score at follow-up was mediated by medial-prefrontal gray matter volume.CONCLUSION: Subthreshold depression in early adolescence might be associated with smaller gray and white matter volumes in regions of the frontal-striatal-limbic affective circuit, and the occurrence of depression in girls with subthreshold depression might be influenced by medial-prefrontal gray matter volume. However, these findings should be interpreted with caution because of the limitations of the clinical assessment methods.",

author = "H{\'e}l{\`e}ne Vulser and Herv{\'e} Lemaitre and Eric Artiges and Ruben Miranda and Jani Penttil{\"a} and Maren Struve and Tahmine Fadai and Viola Kappel and Yvonne Grimmer and Robert Goodman and Argyris Stringaris and Luise Poustka and Patricia Conrod and Vincent Frouin and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Herta Flor and Juergen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Claire Lawrence and Eva Loth and Karl Mann and Frauke Nees and Tomas Paus and Zdenka Pausova and Marcella Rietschel and Robbins, {Trevor W} and Smolka, {Michael N} and Gunter Schumann and Jean-Luc Martinot and Marie-Laure Paill{\`e}re-Martinot and {IMAGEN Consortium (www.imagen-europe.com)}",

year = "2015",

month = oct,

doi = "10.1016/j.jaac.2015.07.006",

language = "English",

volume = "54",

pages = "832--40",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Limited",

number = "10",

}

Vulser, H, Lemaitre, H, Artiges, E, Miranda, R, Penttilä, J, Struve, M, Fadai, T, Kappel, V, Grimmer, Y, Goodman, R , Stringaris, A, Poustka, L, Conrod, P, Frouin, V, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Flor, H, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lawrence, C, Loth, E, Mann, K, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, TW, Smolka, MN, Schumann, G, Martinot, J-L, Paillère-Martinot, M-L & IMAGEN Consortium (www.imagen-europe.com) 2015, 'Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 54, no. 10, pp. 832-40. https://doi.org/10.1016/j.jaac.2015.07.006

TY - JOUR

T1 - Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

AU - Vulser, Hélène

AU - Lemaitre, Hervé

AU - Artiges, Eric

AU - Miranda, Ruben

AU - Penttilä, Jani

AU - Struve, Maren

AU - Fadai, Tahmine

AU - Kappel, Viola

AU - Grimmer, Yvonne

AU - Goodman, Robert

AU - Stringaris, Argyris

AU - Poustka, Luise

AU - Conrod, Patricia

AU - Frouin, Vincent

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Flor, Herta

AU - Gallinat, Juergen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lawrence, Claire

AU - Loth, Eva

AU - Mann, Karl

AU - Nees, Frauke

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Robbins, Trevor W

AU - Smolka, Michael N

AU - Schumann, Gunter

AU - Martinot, Jean-Luc

AU - Paillère-Martinot, Marie-Laure

AU - IMAGEN Consortium (www.imagen-europe.com)

PY - 2015/10

Y1 - 2015/10

N2 - OBJECTIVE: Neuroimaging findings have been reported in regions of the brain associated with emotion in both adults and adolescents with depression, but few studies have investigated whether such brain alterations can be detected in adolescents with subthreshold depression, a condition at risk for major depressive disorder. In this study, we searched for differences in brain structure at age 14 years in adolescents with subthreshold depression and their relation to depression at age 16 years.METHOD: High-resolution structural magnetic resonance imaging was used to assess adolescents with self-reported subthreshold depression (n = 119) and healthy control adolescents (n = 461), all recruited from a community-based sample. Regional gray and white matter volumes were compared across groups using whole-brain voxel-based morphometry. The relationship between subthreshold depression at baseline and depression outcome was explored using causal mediation analyses to search for mediating effects of regional brain volumes.RESULTS: Adolescents with subthreshold depression had smaller gray matter volume in the ventromedial prefrontal and rostral anterior cingulate cortices and caudates, and smaller white matter volumes in the anterior limb of internal capsules, left forceps minor, and right cingulum. In girls, but not in boys, the relation between subthreshold depression at baseline and high depression score at follow-up was mediated by medial-prefrontal gray matter volume.CONCLUSION: Subthreshold depression in early adolescence might be associated with smaller gray and white matter volumes in regions of the frontal-striatal-limbic affective circuit, and the occurrence of depression in girls with subthreshold depression might be influenced by medial-prefrontal gray matter volume. However, these findings should be interpreted with caution because of the limitations of the clinical assessment methods.

AB - OBJECTIVE: Neuroimaging findings have been reported in regions of the brain associated with emotion in both adults and adolescents with depression, but few studies have investigated whether such brain alterations can be detected in adolescents with subthreshold depression, a condition at risk for major depressive disorder. In this study, we searched for differences in brain structure at age 14 years in adolescents with subthreshold depression and their relation to depression at age 16 years.METHOD: High-resolution structural magnetic resonance imaging was used to assess adolescents with self-reported subthreshold depression (n = 119) and healthy control adolescents (n = 461), all recruited from a community-based sample. Regional gray and white matter volumes were compared across groups using whole-brain voxel-based morphometry. The relationship between subthreshold depression at baseline and depression outcome was explored using causal mediation analyses to search for mediating effects of regional brain volumes.RESULTS: Adolescents with subthreshold depression had smaller gray matter volume in the ventromedial prefrontal and rostral anterior cingulate cortices and caudates, and smaller white matter volumes in the anterior limb of internal capsules, left forceps minor, and right cingulum. In girls, but not in boys, the relation between subthreshold depression at baseline and high depression score at follow-up was mediated by medial-prefrontal gray matter volume.CONCLUSION: Subthreshold depression in early adolescence might be associated with smaller gray and white matter volumes in regions of the frontal-striatal-limbic affective circuit, and the occurrence of depression in girls with subthreshold depression might be influenced by medial-prefrontal gray matter volume. However, these findings should be interpreted with caution because of the limitations of the clinical assessment methods.

U2 - 10.1016/j.jaac.2015.07.006

DO - 10.1016/j.jaac.2015.07.006

M3 - Article

C2 - 26407493

SN - 0890-8567

VL - 54

SP - 832

EP - 840

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 10

ER -

Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

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