Successful and unsuccessful recruitment and retainment strategies in a UK multicentre drug trial for a rare chronic pain condition which performed above target

Jatinder Bisla*, Gareth Ambler, Bernhard Frank, Sumit Gulati, Poppy Hocken, Mairi James, Joanna Kelly, Jocelyn Keshet-Price, Candy McCabe, Deborah McGylnn, Nick Padfield, David Pang, Gill Pout, Mark Sanders, Mick Serpell, Nicholas Shenker, Karim Shoukrey, Samuel Wesley, Margaret Weston, Beverly White-AlaoLynne Wyatt, Caroline Murphy, Andreas Goebel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Introduction: Recruitment into trials in rare chronic pain conditions can be challenging, so such trials consequently are underpowered or fail. Methods: Drawing from our experience in conducting, to date, the largest academic trial in a rare chronic pain condition, complex regional pain syndrome, we have identified recruitment and retention strategies for successful trial conduct. Results: We present 13 strategies grouped across the categories of ‘setting the recruitment rate’, ‘networking’, ‘patient information’, ‘trial management’ and ‘patient retention’. Moreover, six recruitment risks are also discussed. A conservative recruitment estimate, based on audits of newly referred patients to the trial centres without taking into account availability of ‘old’ patients or recruitment from outside centres, and assuming a 55% patient refusal rate yielded accurate numbers. Conclusion: Appreciation of these identified recruitment challenges and opportunities may contribute to supporting prospective investigators when they design clinical trials for chronic pain patient population groups where it has been historically difficult to conduct high-quality and robust clinical trials.

Original languageEnglish
JournalBritish Journal of Pain
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Chronic pain
  • complex regional pain syndromes
  • intractable
  • musculoskeletal pain
  • pain
  • pain clinics
  • pain management
  • pain perception
  • pain threshold
  • postoperative

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