Successful clozapine rechallenge following recurrent clozapine-associated pancreatitis: a case report

TY - BOOK

T1 - Successful clozapine rechallenge following recurrent clozapine-associated pancreatitis: a case report

AU - Rodriguez, Victoria

AU - Hanley, Kieran

AU - Julia, Ana

AU - Quattrone, Diego

AU - Kuforiji, Joseph

AU - Whiskey, Eromona

AU - Shergill, Sukhi

PY - 2020

Y1 - 2020

N2 - Background: Acute pancreatitis is a rare but recognised complication of clozapine leading to termination of treatment. Case presentation: We present the case of a 39-year-old man with treatment-resistant schizoaffective disorder and a history of recurrent acute pancreatitis attributed to clozapine. After 15 years of unremitting symptoms with disruptive and aggressive behaviour, he was admitted for a clozapine rechallenge. Despite experiencing two further episodes of acute pancreatitis during clozapine treatment that led to its temporary withdrawal, clozapine was successfully re-established under gastroenterology consultation with close monitoring which resulted in progressively marked improvement of his mental state. Conclusions: This case demonstrates that patients who develop pancreatitis during clozapine treatment may be cautiously rechallenged with specialist gastroenterology support

AB - Background: Acute pancreatitis is a rare but recognised complication of clozapine leading to termination of treatment. Case presentation: We present the case of a 39-year-old man with treatment-resistant schizoaffective disorder and a history of recurrent acute pancreatitis attributed to clozapine. After 15 years of unremitting symptoms with disruptive and aggressive behaviour, he was admitted for a clozapine rechallenge. Despite experiencing two further episodes of acute pancreatitis during clozapine treatment that led to its temporary withdrawal, clozapine was successfully re-established under gastroenterology consultation with close monitoring which resulted in progressively marked improvement of his mental state. Conclusions: This case demonstrates that patients who develop pancreatitis during clozapine treatment may be cautiously rechallenged with specialist gastroenterology support

M3 - Report

BT - Successful clozapine rechallenge following recurrent clozapine-associated pancreatitis: a case report

PB - BMC pharmacology & toxicology

ER -