Successful treatment of aplastic anaemia associated with HIV infection with eltrombopag: implications for a possible immunomodulatory role

Emily E. Bart-Smith, Shahram Kordasti, Austin G. Kulasekararaj, Daniel Richardson, Ghulam J. Mufti, Judith C. W. Marsh*

*Corresponding author for this work

    Research output: Contribution to journalLetterpeer-review

    3 Citations (Scopus)

    Abstract

    We report the first successful treatment with the thrombopoietin receptor mimetic eltrombopag in a patient with severe aplastic anaemia (SAA) associated with HIV infection, thereby avoiding the use of standard immunosuppressive agents for treatment of SAA. Eltrombopag induced a trilineage haematological response. We also show that eltrombopag had an immunomodulatory role with a decrease in proinflammatory T helpers (Th1 and Th17 cells) with increased T-regulatory cell/Thelper ratio, thus contributing to recovery of haemopoiesis.

    Original languageEnglish
    Pages (from-to)2786-2788
    Number of pages3
    JournalAids
    Volume28
    Issue number18
    DOIs
    Publication statusPublished - 28 Nov 2014

    Keywords

    • HUMAN-IMMUNODEFICIENCY-VIRUS
    • THROMBOCYTOPENIA
    • HEMATOPOIESIS
    • CELLS

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