[11C]CO2 to [11C]CO conversion mediated by [11C]silanes: A novel route for [11C] carbonylation reactions

Carlotta Taddei; Salvatore Bongarzone; Abdul Karim Haji Dheere; Antony D. Gee

doi:10.1039/c5cc02095f

[¹¹C]CO₂ to [¹¹C]CO conversion mediated by [¹¹C]silanes: A novel route for [¹¹C] carbonylation reactions

Carlotta Taddei, Salvatore Bongarzone, Abdul Karim Haji Dheere, Antony D. Gee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A novel chemical methodology is described for the conversion of [¹¹C]CO₂ to [¹¹C]CO. Diphenylmethyl silanes trap [¹¹C]CO₂ and release [¹¹C]CO rapidly when triggered by TBAF. Released[¹¹C]CO was used to produce [¹¹C]N-benzylbenzamide and AMPA receptor ligand, [¹¹C]CX546, in radiochemical yields >90% within 6 min from [¹¹C]CO₂ production.

Original language	English
Pages (from-to)	11795-11797
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Volume	51
Issue number	59
Early online date	12 Jun 2015
DOIs	https://doi.org/10.1039/c5cc02095f
Publication status	Published - 28 Jul 2015

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AU - Haji Dheere, Abdul Karim

AU - Gee, Antony D.

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AB - A novel chemical methodology is described for the conversion of [11C]CO2 to [11C]CO. Diphenylmethyl silanes trap [11C]CO2 and release [11C]CO rapidly when triggered by TBAF. Released[11C]CO was used to produce [11C]N-benzylbenzamide and AMPA receptor ligand, [11C]CX546, in radiochemical yields >90% within 6 min from [11C]CO2 production.

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[¹¹C]CO₂ to [¹¹C]CO conversion mediated by [¹¹C]silanes: A novel route for [¹¹C] carbonylation reactions

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