Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

Jasmin Omar, Daniel Ponsford, Cecile Dreiss, Tung-Chun Lee, Xian Jun Loh*

*Corresponding author for this work

Research output: Contribution to journalArticle

46 Citations (Scopus)


Self-assembly of supramolecular hydrogels is driven by dynamic, non-covalent interactions between molecules. Considerable research effort has been exerted to fabricate and optimise supramolecular hydrogels that display shear-thinning, self-healing, and reversibility, in order to develop materials for biomedical applications. This review provides a detailed overview of the chemistry behind the dynamic physicochemical interactions that sustain hydrogel formation (hydrogen bonding, hydrophobic interactions, ionic interactions, metal-ligand coordination, and host-guest interactions). Novel design strategies and methodologies to create supramolecular hydrogels are highlighted, which offer promise for a wide range of applications, specifically drug delivery, wound healing, tissue engineering and 3D bioprinting. To conclude, future prospects are briefly discussed, and consideration given to the steps required to ultimately bring these biomaterials into clinical settings.

Original languageEnglish
Article numbere202200081
Pages (from-to)1-25
JournalChemistry – An Asian Journal
Issue number9
Early online date19 Mar 2022
Publication statusPublished - 19 Mar 2022


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