Surface mechanomyography and electromyography provide non-invasive indices of inspiratory muscle force and activation in healthy subjects

TY - JOUR

T1 - Surface mechanomyography and electromyography provide non-invasive indices of inspiratory muscle force and activation in healthy subjects

AU - Lozano-Garcia, Manuel

AU - Sarlabous, Leonardo

AU - Moxham, John

AU - Rafferty, Gerrard Francis

AU - Torres, Abel

AU - Jane, Raimon

AU - Jolley, Caroline Judith

PY - 2018/11/16

Y1 - 2018/11/16

N2 - The current gold standard assessment of human inspiratory muscle function involves using invasive measures of transdiaphragmatic pressure (Pdi) or crural diaphragm electromyography (oesEMGdi). Mechanomyography is a non-invasive measure of muscle vibration associated with muscle contraction. Surface electromyogram and mechanomyogram, recorded transcutaneously using sensors placed over the lower intercostal spaces (sEMGlic and sMMGlic respectively), have been proposed to provide non-invasive indices of inspiratory muscle activation, but have not been directly compared to gold standard Pdi and oesEMGdi measures during voluntary respiratory manoeuvres. To validate the noninvasive techniques, the relationships between Pdi and sMMGlic, and between oesEMGdi and sEMGlic were measured simultaneously in 12 healthy subjects during an incremental inspiratory threshold loading protocol. Myographic signals were analysed using fxed sample entropy (fSampEn), which is less infuenced by cardiac artefacts than conventional root mean square. Strong correlations were observed between: mean Pdi and mean fSampEn |sMMGlic| (left, 0.76; right, 0.81), the time-integrals of the Pdi and fSampEn |sMMGlic| (left, 0.78; right, 0.83), and mean fSampEn oesEMGdi and mean fSampEn sEMGlic (left, 0.84; right, 0.83). These fndings suggest that sMMGlic and sEMGlic could provide useful noninvasive alternatives to Pdi and oesEMGdi for the assessment of inspiratory muscle function in health and disease.

AB - The current gold standard assessment of human inspiratory muscle function involves using invasive measures of transdiaphragmatic pressure (Pdi) or crural diaphragm electromyography (oesEMGdi). Mechanomyography is a non-invasive measure of muscle vibration associated with muscle contraction. Surface electromyogram and mechanomyogram, recorded transcutaneously using sensors placed over the lower intercostal spaces (sEMGlic and sMMGlic respectively), have been proposed to provide non-invasive indices of inspiratory muscle activation, but have not been directly compared to gold standard Pdi and oesEMGdi measures during voluntary respiratory manoeuvres. To validate the noninvasive techniques, the relationships between Pdi and sMMGlic, and between oesEMGdi and sEMGlic were measured simultaneously in 12 healthy subjects during an incremental inspiratory threshold loading protocol. Myographic signals were analysed using fxed sample entropy (fSampEn), which is less infuenced by cardiac artefacts than conventional root mean square. Strong correlations were observed between: mean Pdi and mean fSampEn |sMMGlic| (left, 0.76; right, 0.81), the time-integrals of the Pdi and fSampEn |sMMGlic| (left, 0.78; right, 0.83), and mean fSampEn oesEMGdi and mean fSampEn sEMGlic (left, 0.84; right, 0.83). These fndings suggest that sMMGlic and sEMGlic could provide useful noninvasive alternatives to Pdi and oesEMGdi for the assessment of inspiratory muscle function in health and disease.

UR - https://www.nature.com/articles/s41598-018-35024-z

U2 - 10.1038/s41598-018-35024-z

DO - 10.1038/s41598-018-35024-z

M3 - Article

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

M1 - 16921

ER -