TY - JOUR
T1 - Sweating and other thermoregulatory abnormalities in Parkinson's disease
T2 - A review
AU - Leta, Valentina
AU - Van Wamelen, Daniel
AU - Rukavina, Katarina
AU - Jaakkola, Elina
AU - Sportelli, Carolina
AU - Wan, Yi Min
AU - Podlewska, Aleksandra
AU - Parry, Miriam
AU - Metta, Vinod
AU - Chaudhuri, Kallol
N1 - Funding Information:
This article represents independent collaborative research part funded by the National Institute for Health Research Biomedical Research Centre at South London and Maudsley National Health Service Foundation Trust and King’s College London.
Publisher Copyright:
© 2019 Annals of Movement Disorders.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Thermoregulatory abnormalities, especially sweating disorders, are very common in Parkinson's disease (PD). The estimated prevalence of sweating abnormalities ranges from 5.5% to 12.9% in de novo, newly diagnosed patients with PD and up to 64% during later stages of the disease. The range of thermoregulatory abnormalities in PD is broad, and includes hyperhidrosis, hypohidrosis, and hypothermia. In addition, the way in which these symptoms present themselves varies between patients and they can be chronic or fluctuating, local or generalized affecting the whole body, and related to motor complications or medication. Often there is a strong link to other autonomic symptoms, yet the exact pathogenesis behind these overlapping symptoms remains largely elusive, although current evidence points toward both central and peripheral involvement. Treatment remains difficult because of the lack of understanding of pathophysiology as well as specific clinical trials needed for evidence base. In this review, we have identified 43 studies in English language assessing sweating disorders in idiopathic PD. Here, we summarize knowledge gleaned from these reports and discuss current understanding of thermoregulatory dysfunction in PD, its phenomenology, pathophysiology, and management options.
AB - Thermoregulatory abnormalities, especially sweating disorders, are very common in Parkinson's disease (PD). The estimated prevalence of sweating abnormalities ranges from 5.5% to 12.9% in de novo, newly diagnosed patients with PD and up to 64% during later stages of the disease. The range of thermoregulatory abnormalities in PD is broad, and includes hyperhidrosis, hypohidrosis, and hypothermia. In addition, the way in which these symptoms present themselves varies between patients and they can be chronic or fluctuating, local or generalized affecting the whole body, and related to motor complications or medication. Often there is a strong link to other autonomic symptoms, yet the exact pathogenesis behind these overlapping symptoms remains largely elusive, although current evidence points toward both central and peripheral involvement. Treatment remains difficult because of the lack of understanding of pathophysiology as well as specific clinical trials needed for evidence base. In this review, we have identified 43 studies in English language assessing sweating disorders in idiopathic PD. Here, we summarize knowledge gleaned from these reports and discuss current understanding of thermoregulatory dysfunction in PD, its phenomenology, pathophysiology, and management options.
KW - Hyperhidrosis
KW - hypohidrosis
KW - hypothermia
KW - Parkinson
KW - sweating
KW - thermoregulatory
UR - http://www.scopus.com/inward/record.url?scp=85088501355&partnerID=8YFLogxK
U2 - 10.4103/AOMD.AOMD_2_19
DO - 10.4103/AOMD.AOMD_2_19
M3 - Review article
AN - SCOPUS:85088501355
SN - 2590-3446
VL - 2
SP - 39
EP - 47
JO - Annals of Movement Disorders
JF - Annals of Movement Disorders
IS - 2
ER -