Symmetric diffeomorphic registration of fibre orientation distributions

TY - JOUR

T1 - Symmetric diffeomorphic registration of fibre orientation distributions

AU - Raffelt, David

AU - Tournier, Jacques-Donald

AU - Fripp, Jurgen

AU - Crozier, Stuart

AU - Connelly, Alan

AU - Salvado, Olivier

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Registration of diffusion-weighted images is an important step in comparing white matter fibre bundles across subjects, or in the same subject at different time points. Using diffusion-weighted imaging, Spherical Deconvolution enables multiple fibre populations within a voxel to be resolved by computing the fibre orientation distribution (FOD). In this paper, we present a novel method that employs FODs for the registration of diffusion-weighted images. Registration was performed by optimising a symmetric diffeomorphic non-linear transformation model, using image metrics based on the mean squared difference, and cross-correlation of the FOD spherical harmonic coefficients. The proposed method was validated by recovering known displacement fields using FODs represented with maximum harmonic degrees (l(max)) of 2.4 and 6. Results demonstrate a benefit in using FODs at l(max) = 4 compared to l(max) = 2. However, a decrease in registration accuracy was observed when l(max) = 6 was used; this was likely caused by noise in higher harmonic degrees. We compared our proposed method to fractional anisotropy driven registration using an identical code base and parameters. FOD registration was observed to perform significantly better than FA in all experiments. The cross-correlation metric performed significantly better than the mean squared difference. Finally, we demonstrated the utility of this method by computing an unbiased group average FOD template that was used for probabilistic fibre tractography. This work suggests that using crossing fibre information aids in the alignment of white matter and could therefore benefit several methods for investigating population differences in white matter, including voxel based analysis, tensor based morphometry, atlas based segmentation and labelling, and group average fibre tractography.

AB - Registration of diffusion-weighted images is an important step in comparing white matter fibre bundles across subjects, or in the same subject at different time points. Using diffusion-weighted imaging, Spherical Deconvolution enables multiple fibre populations within a voxel to be resolved by computing the fibre orientation distribution (FOD). In this paper, we present a novel method that employs FODs for the registration of diffusion-weighted images. Registration was performed by optimising a symmetric diffeomorphic non-linear transformation model, using image metrics based on the mean squared difference, and cross-correlation of the FOD spherical harmonic coefficients. The proposed method was validated by recovering known displacement fields using FODs represented with maximum harmonic degrees (l(max)) of 2.4 and 6. Results demonstrate a benefit in using FODs at l(max) = 4 compared to l(max) = 2. However, a decrease in registration accuracy was observed when l(max) = 6 was used; this was likely caused by noise in higher harmonic degrees. We compared our proposed method to fractional anisotropy driven registration using an identical code base and parameters. FOD registration was observed to perform significantly better than FA in all experiments. The cross-correlation metric performed significantly better than the mean squared difference. Finally, we demonstrated the utility of this method by computing an unbiased group average FOD template that was used for probabilistic fibre tractography. This work suggests that using crossing fibre information aids in the alignment of white matter and could therefore benefit several methods for investigating population differences in white matter, including voxel based analysis, tensor based morphometry, atlas based segmentation and labelling, and group average fibre tractography.

KW - Fibre orientation distribution

KW - Registration

KW - Spatial normalisation

KW - HARDI

KW - Diffusion MRI

KW - DIFFUSION TENSOR IMAGES

KW - SPATIAL NORMALIZATION

KW - SPHERICAL DECONVOLUTION

KW - HUMAN BRAIN

KW - NONRIGID REGISTRATION

KW - MRI

KW - FIELDS

KW - ATLAS

KW - MODEL

KW - TRACTOGRAPHY

U2 - 10.1016/j.neuroimage.2011.02.014

DO - 10.1016/j.neuroimage.2011.02.014

M3 - Article

SN - 1053-8119

VL - 56

SP - 1171

EP - 1180

JO - NeuroImage

JF - NeuroImage

IS - 3

ER -