Synaptic NMDA receptor signalling controls R-type calcium channel recruitment

Zhendong Feng, Oleg O. Glebov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Regulation of extracellular Ca2+ influx by neuronal activity is a key mechanism underlying synaptic plasticity. At the neuronal synapse, activity-dependent Ca2+ entry involves N-methyl-D-aspartate receptors (NMDARs) and voltage-gated calcium channels (VGCCs); the relationship between NMDARs and VGCCs, however, is poorly understood. Here, we report that neuronal activity rapidly (1h) regulates recruitment of R-type VGCCs in hippocampal neurons through synaptic NMDAR signalling. This finding reveals a link between two key neuronal signalling pathways, suggesting a feedback mode for regulation of synaptic Ca2+ signalling.

Original languageEnglish
Pages (from-to)4133-4140
Number of pages8
JournalEuropean Journal of Neuroscience
Volume54
Issue number1
DOIs
Publication statusPublished - Jul 2021

Keywords

  • calcium channels
  • NMDA receptors
  • synapse

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