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Synaptic NMDA receptor signalling controls R-type calcium channel recruitment

Research output: Contribution to journalArticlepeer-review

Zhendong Feng, Oleg O. Glebov

Original languageEnglish
Pages (from-to)4133-4140
Number of pages8
JournalEuropean Journal of Neuroscience
Issue number1
Accepted/In press2021
PublishedJul 2021

Bibliographical note

Funding Information: This work is supported by funding from the Lewy Body Society, Qingdao University and the National Natural Science Foundation of China. Publisher Copyright: © 2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors


Regulation of extracellular Ca2+ influx by neuronal activity is a key mechanism underlying synaptic plasticity. At the neuronal synapse, activity-dependent Ca2+ entry involves N-methyl-D-aspartate receptors (NMDARs) and voltage-gated calcium channels (VGCCs); the relationship between NMDARs and VGCCs, however, is poorly understood. Here, we report that neuronal activity rapidly (1h) regulates recruitment of R-type VGCCs in hippocampal neurons through synaptic NMDAR signalling. This finding reveals a link between two key neuronal signalling pathways, suggesting a feedback mode for regulation of synaptic Ca2+ signalling.

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