Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice

Martin Broadstock; Rikke Lewinsky; Emma L. Jones; Cathy Mitchelmore; David R. Howlett; Paul T. Francis

doi:10.1007/s00702-011-0727-1

Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice

Martin Broadstock, Rikke Lewinsky, Emma L. Jones, Cathy Mitchelmore, David R. Howlett, Paul T. Francis

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Dietary factors may play a role in Alzheimer's disease (AD) pathogenesis. In an effort to recapitulate some of the synaptic protein changes observed in the disease, AD transgenic and wild-type mice were fed either a normal or pro-oxidant diet for 3 months from three months of age. Pro-oxidant diet treatment resulted in altered expression of vesicular glutamate transporter-1 and glutamine synthetase, suggesting changes in glutamatergic synaptic function, and increased expression of urokinase plasminogen activator receptor, possibly reflecting oxidative stress.

Original language	English
Pages (from-to)	493 - 496
Number of pages	4
Journal	Journal of Neural Transmission
Volume	119
Issue number	4
DOIs	https://doi.org/10.1007/s00702-011-0727-1
Publication status	Published - Apr 2012

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abstract = "Dietary factors may play a role in Alzheimer's disease (AD) pathogenesis. In an effort to recapitulate some of the synaptic protein changes observed in the disease, AD transgenic and wild-type mice were fed either a normal or pro-oxidant diet for 3 months from three months of age. Pro-oxidant diet treatment resulted in altered expression of vesicular glutamate transporter-1 and glutamine synthetase, suggesting changes in glutamatergic synaptic function, and increased expression of urokinase plasminogen activator receptor, possibly reflecting oxidative stress.",

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AU - Lewinsky, Rikke

AU - Jones, Emma L.

AU - Mitchelmore, Cathy

AU - Howlett, David R.

AU - Francis, Paul T.

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AB - Dietary factors may play a role in Alzheimer's disease (AD) pathogenesis. In an effort to recapitulate some of the synaptic protein changes observed in the disease, AD transgenic and wild-type mice were fed either a normal or pro-oxidant diet for 3 months from three months of age. Pro-oxidant diet treatment resulted in altered expression of vesicular glutamate transporter-1 and glutamine synthetase, suggesting changes in glutamatergic synaptic function, and increased expression of urokinase plasminogen activator receptor, possibly reflecting oxidative stress.

U2 - 10.1007/s00702-011-0727-1

DO - 10.1007/s00702-011-0727-1

M3 - Article

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SP - 493

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JF - Journal of Neural Transmission

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Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice

Abstract

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