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Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis

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Synchronization of the Normal Human Peripheral Immune System : A Comprehensive Circadian Systems Immunology Analysis. / Beam, Craig A.; Wasserfall, Clive; Woodwyk, Alyssa; Akers, McKenzie K.; Rauch, Heather; Blok, Thomas; Mason, Patrice; Vos, Duncan; Perry, Daniel; Brusko, Todd; Peakman, Mark; Atkinson, Mark.

In: Scientific Reports, Vol. 10, No. 1, 672, 01.12.2020.

Research output: Contribution to journalArticle

Harvard

Beam, CA, Wasserfall, C, Woodwyk, A, Akers, MK, Rauch, H, Blok, T, Mason, P, Vos, D, Perry, D, Brusko, T, Peakman, M & Atkinson, M 2020, 'Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis', Scientific Reports, vol. 10, no. 1, 672. https://doi.org/10.1038/s41598-019-56951-5

APA

Beam, C. A., Wasserfall, C., Woodwyk, A., Akers, M. K., Rauch, H., Blok, T., ... Atkinson, M. (2020). Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis. Scientific Reports, 10(1), [672]. https://doi.org/10.1038/s41598-019-56951-5

Vancouver

Beam CA, Wasserfall C, Woodwyk A, Akers MK, Rauch H, Blok T et al. Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis. Scientific Reports. 2020 Dec 1;10(1). 672. https://doi.org/10.1038/s41598-019-56951-5

Author

Beam, Craig A. ; Wasserfall, Clive ; Woodwyk, Alyssa ; Akers, McKenzie K. ; Rauch, Heather ; Blok, Thomas ; Mason, Patrice ; Vos, Duncan ; Perry, Daniel ; Brusko, Todd ; Peakman, Mark ; Atkinson, Mark. / Synchronization of the Normal Human Peripheral Immune System : A Comprehensive Circadian Systems Immunology Analysis. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex Download

@article{44f05af03b284b748a85013544e2a5b8,
title = "Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis",
abstract = "In this study, we sought to fill an important gap in fundamental immunology research by conducting a comprehensive systems immunology analysis of daily variation in the normal human peripheral immune system. Although variation due to circadian rhythmicity was not a significant source of variation in daily B-cell levels or any CD4+ functional subset, it accounted for more than 25{\%} of CD4+ regulatory T-cell variation and over 50{\%} of CD8+ central memory variation. Circadian rhythmicity demonstrated phase alignment within functional phenotypes. In addition, we observed that previously-described mechanistic relationships can also appear in the peripheral system as phase shifting in rhythmic patterns. We identified a set of immune factors which are ubiquitously correlated with other factors and further analysis also identified a tightly-correlated “core” set whose relational structure persisted after analytically removing circadian-related variation. This core set consisted of CD8+ and its subpopulations and the NK population. In sum, the peripheral immune system can be conceptualized as a dynamic, interconnected wave-field repeating its pattern on a daily basis. Our data provide a comprehensive inventory of synchronization and correlation within this wave-field and we encourage use of our data to discover unknown mechanistic relationships which can then be tested in the laboratory.",
author = "Beam, {Craig A.} and Clive Wasserfall and Alyssa Woodwyk and Akers, {McKenzie K.} and Heather Rauch and Thomas Blok and Patrice Mason and Duncan Vos and Daniel Perry and Todd Brusko and Mark Peakman and Mark Atkinson",
year = "2020",
month = "12",
day = "1",
doi = "10.1038/s41598-019-56951-5",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Synchronization of the Normal Human Peripheral Immune System

T2 - A Comprehensive Circadian Systems Immunology Analysis

AU - Beam, Craig A.

AU - Wasserfall, Clive

AU - Woodwyk, Alyssa

AU - Akers, McKenzie K.

AU - Rauch, Heather

AU - Blok, Thomas

AU - Mason, Patrice

AU - Vos, Duncan

AU - Perry, Daniel

AU - Brusko, Todd

AU - Peakman, Mark

AU - Atkinson, Mark

PY - 2020/12/1

Y1 - 2020/12/1

N2 - In this study, we sought to fill an important gap in fundamental immunology research by conducting a comprehensive systems immunology analysis of daily variation in the normal human peripheral immune system. Although variation due to circadian rhythmicity was not a significant source of variation in daily B-cell levels or any CD4+ functional subset, it accounted for more than 25% of CD4+ regulatory T-cell variation and over 50% of CD8+ central memory variation. Circadian rhythmicity demonstrated phase alignment within functional phenotypes. In addition, we observed that previously-described mechanistic relationships can also appear in the peripheral system as phase shifting in rhythmic patterns. We identified a set of immune factors which are ubiquitously correlated with other factors and further analysis also identified a tightly-correlated “core” set whose relational structure persisted after analytically removing circadian-related variation. This core set consisted of CD8+ and its subpopulations and the NK population. In sum, the peripheral immune system can be conceptualized as a dynamic, interconnected wave-field repeating its pattern on a daily basis. Our data provide a comprehensive inventory of synchronization and correlation within this wave-field and we encourage use of our data to discover unknown mechanistic relationships which can then be tested in the laboratory.

AB - In this study, we sought to fill an important gap in fundamental immunology research by conducting a comprehensive systems immunology analysis of daily variation in the normal human peripheral immune system. Although variation due to circadian rhythmicity was not a significant source of variation in daily B-cell levels or any CD4+ functional subset, it accounted for more than 25% of CD4+ regulatory T-cell variation and over 50% of CD8+ central memory variation. Circadian rhythmicity demonstrated phase alignment within functional phenotypes. In addition, we observed that previously-described mechanistic relationships can also appear in the peripheral system as phase shifting in rhythmic patterns. We identified a set of immune factors which are ubiquitously correlated with other factors and further analysis also identified a tightly-correlated “core” set whose relational structure persisted after analytically removing circadian-related variation. This core set consisted of CD8+ and its subpopulations and the NK population. In sum, the peripheral immune system can be conceptualized as a dynamic, interconnected wave-field repeating its pattern on a daily basis. Our data provide a comprehensive inventory of synchronization and correlation within this wave-field and we encourage use of our data to discover unknown mechanistic relationships which can then be tested in the laboratory.

UR - http://www.scopus.com/inward/record.url?scp=85078243582&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-56951-5

DO - 10.1038/s41598-019-56951-5

M3 - Article

C2 - 31959869

AN - SCOPUS:85078243582

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 672

ER -

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