King's College London

Research portal

Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis

Research output: Contribution to journalArticle

Standard

Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis. / Tsermentseli, Stella; Leigh, P Nigel; Taylor, Lorna J; Radunovic, Aleksandar; Catani, Marco; Goldstein, Laura H.

In: Amyotrophic lateral sclerosis & frontotemporal degeneration, Vol. 17, No. 1-2, 01.02.2016, p. 69-76.

Research output: Contribution to journalArticle

Harvard

Tsermentseli, S, Leigh, PN, Taylor, LJ, Radunovic, A, Catani, M & Goldstein, LH 2016, 'Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis', Amyotrophic lateral sclerosis & frontotemporal degeneration, vol. 17, no. 1-2, pp. 69-76. https://doi.org/10.3109/21678421.2015.1071397

APA

Tsermentseli, S., Leigh, P. N., Taylor, L. J., Radunovic, A., Catani, M., & Goldstein, L. H. (2016). Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration, 17(1-2), 69-76. https://doi.org/10.3109/21678421.2015.1071397

Vancouver

Tsermentseli S, Leigh PN, Taylor LJ, Radunovic A, Catani M, Goldstein LH. Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration. 2016 Feb 1;17(1-2):69-76. https://doi.org/10.3109/21678421.2015.1071397

Author

Tsermentseli, Stella ; Leigh, P Nigel ; Taylor, Lorna J ; Radunovic, Aleksandar ; Catani, Marco ; Goldstein, Laura H. / Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis. In: Amyotrophic lateral sclerosis & frontotemporal degeneration. 2016 ; Vol. 17, No. 1-2. pp. 69-76.

Bibtex Download

@article{547c3efa7570465e977b9f0cc683190e,
title = "Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis",
abstract = "Despite recent interest in cognitive changes in patients with amyotrophic lateral sclerosis (ALS), investigations of language function looking at the level of word, sentence and discourse processing are relatively scarce. Data were obtained from 26 patients with sporadic ALS and 26 healthy controls matched for age, education, gender, anxiety, depression and executive function performance. Standardized language tasks included confrontation naming, semantic access, and syntactic comprehension. Quantitative production analysis (QPA) was used to analyse connected speech samples of the Cookie Theft picture description task. Results showed that the ALS patients were impaired on standardized measures of grammatical comprehension and action/verb semantics. At the level of discourse, ALS patients were impaired on measures of syntactic complexity and fluency; however, the latter could be better explained by disease related factors. Discriminant analysis revealed that syntactic measures differentiated ALS patients from controls. In conclusion, patients with ALS exhibit deficits in receptive and expressive language on tasks of comprehension and connected speech production, respectively. Our findings suggest that syntactic processing deficits seem to be the predominant feature of language impairment in ALS and that these deficits can be detected by relatively simple language tests.",
author = "Stella Tsermentseli and Leigh, {P Nigel} and Taylor, {Lorna J} and Aleksandar Radunovic and Marco Catani and Goldstein, {Laura H}",
year = "2016",
month = feb,
day = "1",
doi = "10.3109/21678421.2015.1071397",
language = "English",
volume = "17",
pages = "69--76",
journal = "Amyotrophic lateral sclerosis & frontotemporal degeneration",
issn = "2167-8421",
publisher = "Taylor & Francis",
number = "1-2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis

AU - Tsermentseli, Stella

AU - Leigh, P Nigel

AU - Taylor, Lorna J

AU - Radunovic, Aleksandar

AU - Catani, Marco

AU - Goldstein, Laura H

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Despite recent interest in cognitive changes in patients with amyotrophic lateral sclerosis (ALS), investigations of language function looking at the level of word, sentence and discourse processing are relatively scarce. Data were obtained from 26 patients with sporadic ALS and 26 healthy controls matched for age, education, gender, anxiety, depression and executive function performance. Standardized language tasks included confrontation naming, semantic access, and syntactic comprehension. Quantitative production analysis (QPA) was used to analyse connected speech samples of the Cookie Theft picture description task. Results showed that the ALS patients were impaired on standardized measures of grammatical comprehension and action/verb semantics. At the level of discourse, ALS patients were impaired on measures of syntactic complexity and fluency; however, the latter could be better explained by disease related factors. Discriminant analysis revealed that syntactic measures differentiated ALS patients from controls. In conclusion, patients with ALS exhibit deficits in receptive and expressive language on tasks of comprehension and connected speech production, respectively. Our findings suggest that syntactic processing deficits seem to be the predominant feature of language impairment in ALS and that these deficits can be detected by relatively simple language tests.

AB - Despite recent interest in cognitive changes in patients with amyotrophic lateral sclerosis (ALS), investigations of language function looking at the level of word, sentence and discourse processing are relatively scarce. Data were obtained from 26 patients with sporadic ALS and 26 healthy controls matched for age, education, gender, anxiety, depression and executive function performance. Standardized language tasks included confrontation naming, semantic access, and syntactic comprehension. Quantitative production analysis (QPA) was used to analyse connected speech samples of the Cookie Theft picture description task. Results showed that the ALS patients were impaired on standardized measures of grammatical comprehension and action/verb semantics. At the level of discourse, ALS patients were impaired on measures of syntactic complexity and fluency; however, the latter could be better explained by disease related factors. Discriminant analysis revealed that syntactic measures differentiated ALS patients from controls. In conclusion, patients with ALS exhibit deficits in receptive and expressive language on tasks of comprehension and connected speech production, respectively. Our findings suggest that syntactic processing deficits seem to be the predominant feature of language impairment in ALS and that these deficits can be detected by relatively simple language tests.

U2 - 10.3109/21678421.2015.1071397

DO - 10.3109/21678421.2015.1071397

M3 - Article

C2 - 26312952

VL - 17

SP - 69

EP - 76

JO - Amyotrophic lateral sclerosis & frontotemporal degeneration

JF - Amyotrophic lateral sclerosis & frontotemporal degeneration

SN - 2167-8421

IS - 1-2

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454