Abstract
We report examples of a series of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogues 12–15 prepared from a common functionalized building block 11 that can be conveniently synthesized on a large scale and in optically pure form. Isoindoline analogue 15 is the most cytotoxic agent in this series, has the highest DNA-binding affinity, and shows significant activity in the in vivo hollow fibre assay.
Original language | English |
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Pages (from-to) | 901-904 |
Number of pages | 4 |
Journal | Bioorganic & medicinal chemistry letters |
Volume | 14 |
Issue number | 4 |
DOIs | |
Publication status | Published - 23 Feb 2004 |