Synthesis and cell-adhesion properties of cyclo(-arg-gly-asp-ser-lys-), a constrained analogue of the active domain of fibronectin

TY - JOUR

T1 - Synthesis and cell-adhesion properties of cyclo(-arg-gly-asp-ser-lys-), a constrained analogue of the active domain of fibronectin

AU - Davies, John S.

AU - Enjalbal, Christine

AU - Wise, Clare J.

AU - Webb, Sarah E.

AU - Jones, Gareth E.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - Details of the synthesis of the protected pentapeptide linear precursor on a resin with an acid-labile linker, and its subsequent cyclisation to cyclo(-Arg-Gly-Asp-Ser-Lys-) are presented. The cyclopentapeptide, which is known to exist in solution in a β- and γ-turn conformation, shows specific differences in its effect on adhesion and cell spreading for fibroblast 3T3 and macrophage Bac 1 cells.

AB - Details of the synthesis of the protected pentapeptide linear precursor on a resin with an acid-labile linker, and its subsequent cyclisation to cyclo(-Arg-Gly-Asp-Ser-Lys-) are presented. The cyclopentapeptide, which is known to exist in solution in a β- and γ-turn conformation, shows specific differences in its effect on adhesion and cell spreading for fibroblast 3T3 and macrophage Bac 1 cells.

UR - http://www.scopus.com/inward/record.url?scp=37049079636&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:37049079636

SN - 1472-7781

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 14

ER -