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Synthesis and in vitro cytotoxicity studies of Pd(II) and Pt(II) acetamide complexes: Molecular structures of trans-[PdCl2(bzmta)2].DMF (bzmta = 2-acetylamino-6-methylbenzothiazole) and cis-[PtCl2(bzta)2].2DMF (bzta = 2-acetylaminobenzothiazole)

Research output: Contribution to journalArticle

Ahmed S. Al-Janabi, Waseem A. Al-Jumaili, Lamaan J. Al-Hayaly, Subhi A. Al-Jibori, Harry Schmidt, Christoph Wagner, Graeme Hogarth

Original languageEnglish
Article number114591
JournalPOLYHEDRON
Volume185
DOIs
Published15 Jul 2020

King's Authors

Abstract

Trans-[PdCl2(bzta)2] (bzta = 2-acetylaminobenzothiazole) (1a), trans-[PdCl2(bzmta)2] (bzmtaH = 2-acetylamino-6-methylbenzothiazole) (1b), trans-[PdCl2(bzcta)2] {bzcta = 2-acetylamino(6-chlorobenzothiazole)} (1c), cis-[PtCl2(bzta)2] (2a), cis-[PtCl2(bzmta)2] (2b) and cis-[PtCl2(bzcta)2] (2c) have synthesized and fully characterized; the molecular structures of 1b.dmf and 2a.2dmf reveal that the acetamide ligands are coordinated through the nitrogen atom of the heterocyclic ring. The anticancer effects of 1a and 2a-c were tested against a wide-range of cancer cell lines. All show cytotoxic activity, but are less effective than cis-platin. Unexpectedly, the palladium complex 1a was more active than the platinum complexes 2a-c, suggesting that future studies on related palladium complexes may be fruitful.

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