TY - JOUR
T1 - Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins
T2 - Effect of PEG chain length, coordinated metal, and axial ligand
AU - Mewis, Ryan E.
AU - Savoie, Huguette
AU - Archibald, Stephen J.
AU - Boyle, Ross W.
PY - 2009/9
Y1 - 2009/9
N2 - Treatment of 5,10,15,20-tetra(pentafluorophenyl) porphyrins with polyethylene glycol (PEG) halides and sodium sulfide is a mild and efficient route to water-soluble PEG substituted porphyrins. The method has been used to access a series of free-base and metallated PEG porphyrins, which have been investigated for photodynamic activity against Human Caucasian colon adenocarcinoma (Caco2) cells. Toxicity, in the presence and absence of light, is shown to be affected by the length of the PEG chain, nature of coordinated metal and axial ligand.
AB - Treatment of 5,10,15,20-tetra(pentafluorophenyl) porphyrins with polyethylene glycol (PEG) halides and sodium sulfide is a mild and efficient route to water-soluble PEG substituted porphyrins. The method has been used to access a series of free-base and metallated PEG porphyrins, which have been investigated for photodynamic activity against Human Caucasian colon adenocarcinoma (Caco2) cells. Toxicity, in the presence and absence of light, is shown to be affected by the length of the PEG chain, nature of coordinated metal and axial ligand.
KW - Ligand
KW - Metal
KW - PEG
KW - Porphyrin
UR - http://www.scopus.com/inward/record.url?scp=70449642375&partnerID=8YFLogxK
U2 - 10.1016/j.pdpdt.2009.08.002
DO - 10.1016/j.pdpdt.2009.08.002
M3 - Article
C2 - 19932452
AN - SCOPUS:70449642375
SN - 1572-1000
VL - 6
SP - 200
EP - 206
JO - Photodiagnosis and Photodynamic Therapy
JF - Photodiagnosis and Photodynamic Therapy
IS - 3-4
ER -
