Synthesis and 68Ga radiolabelling of calcium alginate beads for Positron Emission Particle Tracking (PEPT) applications

Juan Pellico; Ananda Jadhav; Laurence Vass; Agathe Bricout; Mostafa Barigou; Paul Marsden; Rafael T. M. de Rosales

doi:10.1016/j.ces.2022.118159

Synthesis and ⁶⁸Ga radiolabelling of calcium alginate beads for Positron Emission Particle Tracking (PEPT) applications

Juan Pellico ^*, Ananda Jadhav, Laurence Vass, Agathe Bricout, Mostafa Barigou, Paul Marsden, Rafael T. M. de Rosales^*

^*Corresponding author for this work

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Abstract

Positron emission particle tracking (PEPT) relies on the back-to-back γ-rays generated through a positron annihilation to track a single radiolabelled particle in three dimensions and in dense, multiphase, and opaque systems. The spectrum of applications of PEPT such as batch mixing systems in chemical, food and pharmaceutical sectors or granulation, die-filling and fluidisation in industrial processes, is directly related to the development of efficient radiolabelled materials and often restricted due to the lack of suitable materials with adequate radiochemical properties. In this work, we report a straightforward synthesis and radiolabelling of calcium alginate beads of different size, specific surface, concentration, and density, with the positron emitter gallium-68 (68Ga) to cover a broad range of possibilities in PEPT. We demonstrate a high intrinsic affinity between alginate and 68Ga providing directly radiolabelled particles with excellent radiochemical properties and excellent performance for tracking complex trajectories. These results, in combination with the availability and relatively simple chemistry of 68Ga, provide a high versatile and straightforward platform for the future development and advance of PEPT in different applications.

Original language	English
Article number	118159
Journal	CHEMICAL ENGINEERING SCIENCE
Volume	264
DOIs	https://doi.org/10.1016/j.ces.2022.118159
Publication status	Published - 12 Oct 2022

Keywords

Calcium Alginate beads
Ga-68
PEPT
Preclinical scanner
Radiolabelled materials

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10.1016/j.ces.2022.118159

Synthesis and 68Ga radiolabelling of calcium alginate beads for positron emission particle tracking applicationsFinal published version, 1.4 MBLicence: CC BY

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@article{8709a113c3b740db81144c47f3c215cd,

title = "Synthesis and 68Ga radiolabelling of calcium alginate beads for Positron Emission Particle Tracking (PEPT) applications",

abstract = "Positron emission particle tracking (PEPT) relies on the back-to-back γ-rays generated through a positron annihilation to track a single radiolabelled particle in three dimensions and in dense, multiphase, and opaque systems. The spectrum of applications of PEPT such as batch mixing systems in chemical, food and pharmaceutical sectors or granulation, die-filling and fluidisation in industrial processes, is directly related to the development of efficient radiolabelled materials and often restricted due to the lack of suitable materials with adequate radiochemical properties. In this work, we report a straightforward synthesis and radiolabelling of calcium alginate beads of different size, specific surface, concentration, and density, with the positron emitter gallium-68 (68Ga) to cover a broad range of possibilities in PEPT. We demonstrate a high intrinsic affinity between alginate and 68Ga providing directly radiolabelled particles with excellent radiochemical properties and excellent performance for tracking complex trajectories. These results, in combination with the availability and relatively simple chemistry of 68Ga, provide a high versatile and straightforward platform for the future development and advance of PEPT in different applications. ",

keywords = "Calcium Alginate beads, Ga-68, PEPT, Preclinical scanner, Radiolabelled materials",

author = "Juan Pellico and Ananda Jadhav and Laurence Vass and Agathe Bricout and Mostafa Barigou and Paul Marsden and {T. M. de Rosales}, Rafael",

note = "Funding Information: The authors wish to thank Professor David Parker (University of Birmingham) for his help with the PEPT phantom. This work was funded by EPSRC programme grants EP/S032789/1 (Probing Multiscale Complex Multiphase Flows with Positrons for Engineering and Biomedical Applications) and EP/R045046/1 (Next Generation Molecular Imaging and Therapy with Radionuclides). We also acknowledge support from the Wellcome/EPSRC Centre for Medical Engineering [WT/203148/Z/16/Z] and the KCL and UCL Comprehensive Cancer Imaging Centre funded by CRUK and EPSRC in association with the MRC and DoH (England). Radioanalytical equipment was funded by a Wellcome Trust Multiuser Equipment Grant: A multiuser radioanalytical facility for molecular imaging and radionuclide therapy research [212885/Z/18/Z]. The authors finally acknowledge support the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust and KCL [grant number IS-BRC-1215-20006]. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. This research was funded in part, by the Wellcome Trust [WT 203148/Z/16/Z][212885/Z/18/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = oct,

day = "12",

doi = "10.1016/j.ces.2022.118159",

language = "English",

volume = "264",

journal = "CHEMICAL ENGINEERING SCIENCE",

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publisher = "Elsevier BV",

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TY - JOUR

T1 - Synthesis and 68Ga radiolabelling of calcium alginate beads for Positron Emission Particle Tracking (PEPT) applications

AU - Pellico , Juan

AU - Jadhav, Ananda

AU - Vass, Laurence

AU - Bricout, Agathe

AU - Barigou, Mostafa

AU - Marsden, Paul

AU - T. M. de Rosales, Rafael

N1 - Funding Information: The authors wish to thank Professor David Parker (University of Birmingham) for his help with the PEPT phantom. This work was funded by EPSRC programme grants EP/S032789/1 (Probing Multiscale Complex Multiphase Flows with Positrons for Engineering and Biomedical Applications) and EP/R045046/1 (Next Generation Molecular Imaging and Therapy with Radionuclides). We also acknowledge support from the Wellcome/EPSRC Centre for Medical Engineering [WT/203148/Z/16/Z] and the KCL and UCL Comprehensive Cancer Imaging Centre funded by CRUK and EPSRC in association with the MRC and DoH (England). Radioanalytical equipment was funded by a Wellcome Trust Multiuser Equipment Grant: A multiuser radioanalytical facility for molecular imaging and radionuclide therapy research [212885/Z/18/Z]. The authors finally acknowledge support the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and KCL [grant number IS-BRC-1215-20006]. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. This research was funded in part, by the Wellcome Trust [WT 203148/Z/16/Z][212885/Z/18/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: © 2022 The Authors

PY - 2022/10/12

Y1 - 2022/10/12

N2 - Positron emission particle tracking (PEPT) relies on the back-to-back γ-rays generated through a positron annihilation to track a single radiolabelled particle in three dimensions and in dense, multiphase, and opaque systems. The spectrum of applications of PEPT such as batch mixing systems in chemical, food and pharmaceutical sectors or granulation, die-filling and fluidisation in industrial processes, is directly related to the development of efficient radiolabelled materials and often restricted due to the lack of suitable materials with adequate radiochemical properties. In this work, we report a straightforward synthesis and radiolabelling of calcium alginate beads of different size, specific surface, concentration, and density, with the positron emitter gallium-68 (68Ga) to cover a broad range of possibilities in PEPT. We demonstrate a high intrinsic affinity between alginate and 68Ga providing directly radiolabelled particles with excellent radiochemical properties and excellent performance for tracking complex trajectories. These results, in combination with the availability and relatively simple chemistry of 68Ga, provide a high versatile and straightforward platform for the future development and advance of PEPT in different applications.

AB - Positron emission particle tracking (PEPT) relies on the back-to-back γ-rays generated through a positron annihilation to track a single radiolabelled particle in three dimensions and in dense, multiphase, and opaque systems. The spectrum of applications of PEPT such as batch mixing systems in chemical, food and pharmaceutical sectors or granulation, die-filling and fluidisation in industrial processes, is directly related to the development of efficient radiolabelled materials and often restricted due to the lack of suitable materials with adequate radiochemical properties. In this work, we report a straightforward synthesis and radiolabelling of calcium alginate beads of different size, specific surface, concentration, and density, with the positron emitter gallium-68 (68Ga) to cover a broad range of possibilities in PEPT. We demonstrate a high intrinsic affinity between alginate and 68Ga providing directly radiolabelled particles with excellent radiochemical properties and excellent performance for tracking complex trajectories. These results, in combination with the availability and relatively simple chemistry of 68Ga, provide a high versatile and straightforward platform for the future development and advance of PEPT in different applications.

KW - Calcium Alginate beads

KW - Ga-68

KW - PEPT

KW - Preclinical scanner

KW - Radiolabelled materials

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U2 - 10.1016/j.ces.2022.118159

DO - 10.1016/j.ces.2022.118159

M3 - Article

AN - SCOPUS:85139733404

SN - 0009-2509

VL - 264

JO - CHEMICAL ENGINEERING SCIENCE

JF - CHEMICAL ENGINEERING SCIENCE

M1 - 118159

ER -

Synthesis and ⁶⁸Ga radiolabelling of calcium alginate beads for Positron Emission Particle Tracking (PEPT) applications

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