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Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV)

Research output: Contribution to journalArticle

Andrea Magri, Omar Mokrane, Kate Lauder, Arvind H. Patel, Daniele Castagnolo

Original languageEnglish
Pages (from-to)724-728
Number of pages5
JournalBIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
Volume29
Issue number5
DOIs
Publication statusPublished - 1 Mar 2019

King's Authors

Abstract

Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.

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