Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units

H Neubert; A T Kicman; D A Cowan; S S Bansal

doi:10.1016/S0040-4039(02)01522-8

Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units

H Neubert, A T Kicman, D A Cowan, S S Bansal

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The synthesis of a novel dendron and dendrimer with potential application in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is described. The dendrimer branching unit was designed to have structural similarities to cinnamic acid based matrices used in MALDI MS. Branching was incorporated into the structure by introducing a second acrylic acid side chain. Some intermediates of the monomer synthesis were shown to function as MALDI matrices. A second-generation dendron was assembled on a solid support employing an N-to-C directed convergent synthetic strategy. Coupling of the dendrons with a trivalent core molecule resulted in a second generation dendrimer. (C) 2002 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	6723 - 6727
Number of pages	5
Journal	TETRAHEDRON LETTERS
Volume	43
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4039(02)01522-8
Publication status	Published - 16 Sept 2002

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title = "Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units",

abstract = "The synthesis of a novel dendron and dendrimer with potential application in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is described. The dendrimer branching unit was designed to have structural similarities to cinnamic acid based matrices used in MALDI MS. Branching was incorporated into the structure by introducing a second acrylic acid side chain. Some intermediates of the monomer synthesis were shown to function as MALDI matrices. A second-generation dendron was assembled on a solid support employing an N-to-C directed convergent synthetic strategy. Coupling of the dendrons with a trivalent core molecule resulted in a second generation dendrimer. (C) 2002 Elsevier Science Ltd. All rights reserved.",

author = "H Neubert and Kicman, {A T} and Cowan, {D A} and Bansal, {S S}",

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AU - Neubert, H

AU - Kicman, A T

AU - Cowan, D A

AU - Bansal, S S

PY - 2002/9/16

Y1 - 2002/9/16

N2 - The synthesis of a novel dendron and dendrimer with potential application in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is described. The dendrimer branching unit was designed to have structural similarities to cinnamic acid based matrices used in MALDI MS. Branching was incorporated into the structure by introducing a second acrylic acid side chain. Some intermediates of the monomer synthesis were shown to function as MALDI matrices. A second-generation dendron was assembled on a solid support employing an N-to-C directed convergent synthetic strategy. Coupling of the dendrons with a trivalent core molecule resulted in a second generation dendrimer. (C) 2002 Elsevier Science Ltd. All rights reserved.

AB - The synthesis of a novel dendron and dendrimer with potential application in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) is described. The dendrimer branching unit was designed to have structural similarities to cinnamic acid based matrices used in MALDI MS. Branching was incorporated into the structure by introducing a second acrylic acid side chain. Some intermediates of the monomer synthesis were shown to function as MALDI matrices. A second-generation dendron was assembled on a solid support employing an N-to-C directed convergent synthetic strategy. Coupling of the dendrons with a trivalent core molecule resulted in a second generation dendrimer. (C) 2002 Elsevier Science Ltd. All rights reserved.

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U2 - 10.1016/S0040-4039(02)01522-8

DO - 10.1016/S0040-4039(02)01522-8

M3 - Article

VL - 43

SP - 6723

EP - 6727

JO - TETRAHEDRON LETTERS

JF - TETRAHEDRON LETTERS

IS - 38

ER -

Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units

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