Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine

Gyoung-Dong Kang, Philip W Howard, David E Thurston

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.
Original languageEnglish
Pages (from-to)1688-9
Number of pages2
JournalCHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Issue number14
Publication statusPublished - 21 Jul 2003

Keywords

  • Antibiotics, Antineoplastic
  • Benzodiazepines
  • Pyrroles
  • Streptomyces

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