King's College London

Research portal

Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics

Research output: Contribution to journalArticle

Steven Yap, Huguette Savoie, Isaline Renard, Benjamin Burke, Harry Sample, Saul Michue-Seijas, Steve Archibald, Ross W. Boyle, Graeme Stasiuk

Original languageEnglish
Pages (from-to)11090-11093
Number of pages4
JournalChemical communications (Cambridge, England)
Issue number75
Publication statusPublished - 25 Sep 2020

King's Authors


The goal of "personalised" medicine has seen a growing interest in the development of theranostic agents. Bifunctional, and targeted-trifunctional, theranostic water-soluble porphyrins with a histidine-like chelating group have been synthesised via copper-catalysed azide-alkyne cycloaddition (CuAAC) "click" chemistry in high yield and purity. They are capable of photodynamic treatment and [99mTc(CO)3]+ complexation for single-photon emission computed tomography (SPECT) imaging, with a radiochemical yield of >95%. The toxicity and phototoxicity were evaluated on HT-29 cells, DU145, and DU145-PSMA cell lines, with the targeted theranostic showing more potent phototoxicity towards DU145-PSMA expressing cells.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454