Synthesis of [18F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours

F. Pisaneschi; Timothy H. Witney; L. Iddon; E.O. Aboagye

doi:10.1039/c3md00169e

Synthesis of [¹⁸F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours

F. Pisaneschi, Timothy H. Witney, L. Iddon, E.O. Aboagye

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

[18F]Fluoro-pivalic acid ([18F]FPIA), an analogue of [18F]fluoroacetate bearing a dimethyl moiety on C-2, has been radiosynthesised and evaluated in vivo. [18F]FPIA has high tumour uptake and, unlike [18F]fluoroacetate, does not defluorinate. © 2013 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1350-1353
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	10
DOIs	https://doi.org/10.1039/c3md00169e
Publication status	Published - 18 Jul 2013

Access to Document

10.1039/c3md00169e

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84884741348&doi=10.1039%2fc3md00169e&partnerID=40&md5=4d265f3605a892b6d4522492aed1452c

Cite this

@article{73e0e630b17f47c697c17a046093f313,

title = "Synthesis of [18F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours",

abstract = "[18F]Fluoro-pivalic acid ([18F]FPIA), an analogue of [18F]fluoroacetate bearing a dimethyl moiety on C-2, has been radiosynthesised and evaluated in vivo. [18F]FPIA has high tumour uptake and, unlike [18F]fluoroacetate, does not defluorinate. {\textcopyright} 2013 The Royal Society of Chemistry.",

author = "F. Pisaneschi and Witney, {Timothy H.} and L. Iddon and E.O. Aboagye",

year = "2013",

month = jul,

day = "18",

doi = "10.1039/c3md00169e",

language = "English",

volume = "4",

pages = "1350--1353",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - Synthesis of [18F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours

AU - Pisaneschi, F.

AU - Witney, Timothy H.

AU - Iddon, L.

AU - Aboagye, E.O.

PY - 2013/7/18

Y1 - 2013/7/18

N2 - [18F]Fluoro-pivalic acid ([18F]FPIA), an analogue of [18F]fluoroacetate bearing a dimethyl moiety on C-2, has been radiosynthesised and evaluated in vivo. [18F]FPIA has high tumour uptake and, unlike [18F]fluoroacetate, does not defluorinate. © 2013 The Royal Society of Chemistry.

AB - [18F]Fluoro-pivalic acid ([18F]FPIA), an analogue of [18F]fluoroacetate bearing a dimethyl moiety on C-2, has been radiosynthesised and evaluated in vivo. [18F]FPIA has high tumour uptake and, unlike [18F]fluoroacetate, does not defluorinate. © 2013 The Royal Society of Chemistry.

U2 - 10.1039/c3md00169e

DO - 10.1039/c3md00169e

M3 - Article

SN - 2040-2503

VL - 4

SP - 1350

EP - 1353

JO - MedChemComm

JF - MedChemComm

IS - 10

ER -

Synthesis of [18F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours

Abstract

Access to Document

Fingerprint

Cite this

Synthesis of [¹⁸F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours