Abstract
We report the synthesis of novel A-C8/C-C2 amide-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers (4a and 4b) via convergent routes. These compounds lack the potent DNA interstrand cross-linking ability and resultant pronounced cytotoxicity of the known A-C8/A-C8' linked dimers (e.g., 2a-b).
Original language | English |
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Pages (from-to) | 2277-80 |
Number of pages | 4 |
Journal | BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS |
Volume | 13 |
Issue number | 14 |
Publication status | Published - 21 Jul 2003 |
Keywords
- Amides
- Aniline Compounds
- Antineoplastic Agents
- Azepines
- Benzodiazepines
- Cross-Linking Reagents
- DNA
- Indicators and Reagents
- Magnetic Resonance Spectroscopy
- Pyrroles