Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

Stephen J Gregson, Philip W Howard, David E Thurston

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20 Citations (Scopus)

Abstract

We report the synthesis of novel A-C8/C-C2 amide-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers (4a and 4b) via convergent routes. These compounds lack the potent DNA interstrand cross-linking ability and resultant pronounced cytotoxicity of the known A-C8/A-C8' linked dimers (e.g., 2a-b).
Original languageEnglish
Pages (from-to)2277-80
Number of pages4
JournalBIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
Volume13
Issue number14
Publication statusPublished - 21 Jul 2003

Keywords

  • Amides
  • Aniline Compounds
  • Antineoplastic Agents
  • Azepines
  • Benzodiazepines
  • Cross-Linking Reagents
  • DNA
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Pyrroles

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