Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex

Kogularamanan  Suntharalingam; Deepali Gupta; Pablo J. Sanz Miguel; Bernhard Lippert; Ramon Vilar

doi:10.1002/chem.200903501

Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex

Kogularamanan Suntharalingam, Deepali Gupta, Pablo J. Sanz Miguel, Bernhard Lippert^*, Ramon Vilar

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

(Figure Presented) A golden quadruplex DNA: A new gold(III) pyrazolylpyridine complex has been synthesised and structurally characterised. The complex displays π-π interactions in the solid state. The DNA binding properties of the complex have been studied by fluorescent intercalator displacement assay, surface plasmon resonance and circular dichroism. These have shown that the complex interacts strongly with quadruplex DNA, in particular with c-myc. CD spectroscopy has also shown the ability of the complex to template the formation of a quadruplex structure from a singly stranded sequence of telomeric DNA (see picture for a qualitative docking of the complex on top of a quadruplex DNA structure).

Original language	English
Pages (from-to)	3613-3616
Number of pages	4
Journal	Chemistry (Weinheim an der Bergstrasse, Germany)
Volume	16
Issue number	12
DOIs	https://doi.org/10.1002/chem.200903501
Publication status	Published - 22 Mar 2010

Keywords

Bioinorganic chemistry
Coordination chemistry
Gold
Quadruplex DNA
Telomere

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10.1002/chem.200903501

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title = "Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex",

abstract = "(Figure Presented) A golden quadruplex DNA: A new gold(III) pyrazolylpyridine complex has been synthesised and structurally characterised. The complex displays π-π interactions in the solid state. The DNA binding properties of the complex have been studied by fluorescent intercalator displacement assay, surface plasmon resonance and circular dichroism. These have shown that the complex interacts strongly with quadruplex DNA, in particular with c-myc. CD spectroscopy has also shown the ability of the complex to template the formation of a quadruplex structure from a singly stranded sequence of telomeric DNA (see picture for a qualitative docking of the complex on top of a quadruplex DNA structure).",

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author = "Kogularamanan Suntharalingam and Deepali Gupta and {Sanz Miguel}, {Pablo J.} and Bernhard Lippert and Ramon Vilar",

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AU - Suntharalingam, Kogularamanan

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AU - Sanz Miguel, Pablo J.

AU - Lippert, Bernhard

AU - Vilar, Ramon

PY - 2010/3/22

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N2 - (Figure Presented) A golden quadruplex DNA: A new gold(III) pyrazolylpyridine complex has been synthesised and structurally characterised. The complex displays π-π interactions in the solid state. The DNA binding properties of the complex have been studied by fluorescent intercalator displacement assay, surface plasmon resonance and circular dichroism. These have shown that the complex interacts strongly with quadruplex DNA, in particular with c-myc. CD spectroscopy has also shown the ability of the complex to template the formation of a quadruplex structure from a singly stranded sequence of telomeric DNA (see picture for a qualitative docking of the complex on top of a quadruplex DNA structure).

AB - (Figure Presented) A golden quadruplex DNA: A new gold(III) pyrazolylpyridine complex has been synthesised and structurally characterised. The complex displays π-π interactions in the solid state. The DNA binding properties of the complex have been studied by fluorescent intercalator displacement assay, surface plasmon resonance and circular dichroism. These have shown that the complex interacts strongly with quadruplex DNA, in particular with c-myc. CD spectroscopy has also shown the ability of the complex to template the formation of a quadruplex structure from a singly stranded sequence of telomeric DNA (see picture for a qualitative docking of the complex on top of a quadruplex DNA structure).

KW - Bioinorganic chemistry

KW - Coordination chemistry

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KW - Quadruplex DNA

KW - Telomere

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Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex

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