Synthesis, structures and cytotoxicity studies of: P -sulfonatocalix[4]arene lanthanide complexes

David M. Miller-Shakesby; Benjamin P. Burke; Shubhanchi Nigam; Graeme J. Stasiuk; Timothy J. Prior; Stephen J. Archibald; Carl Redshaw

doi:10.1039/c6ce00209a

Synthesis, structures and cytotoxicity studies of: P -sulfonatocalix[4]arene lanthanide complexes

David M. Miller-Shakesby, Benjamin P. Burke, Shubhanchi Nigam, Graeme J. Stasiuk, Timothy J. Prior, Stephen J. Archibald^*, Carl Redshaw

^*Corresponding author for this work

Imaging Chemistry & Biology

University of Hull

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC₅₀ values in the range 30-170 μM.

Original language	English
Pages (from-to)	4977-4987
Number of pages	11
Journal	CRYSTENGCOMM
Volume	18
Issue number	26
DOIs	https://doi.org/10.1039/c6ce00209a
Publication status	Published - 1 Jan 2016

Access to Document

10.1039/c6ce00209a

Cite this

@article{8acf5a1c2d234810af7879c9c4743faa,

title = "Synthesis, structures and cytotoxicity studies of: P -sulfonatocalix[4]arene lanthanide complexes",

abstract = "A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC50 values in the range 30-170 μM.",

author = "Miller-Shakesby, {David M.} and Burke, {Benjamin P.} and Shubhanchi Nigam and Stasiuk, {Graeme J.} and Prior, {Timothy J.} and Archibald, {Stephen J.} and Carl Redshaw",

year = "2016",

month = jan,

day = "1",

doi = "10.1039/c6ce00209a",

language = "English",

volume = "18",

pages = "4977--4987",

journal = "CRYSTENGCOMM",

issn = "1466-8033",

publisher = "Royal Society of Chemistry",

number = "26",

}

TY - JOUR

T1 - Synthesis, structures and cytotoxicity studies of

T2 - P -sulfonatocalix[4]arene lanthanide complexes

AU - Miller-Shakesby, David M.

AU - Burke, Benjamin P.

AU - Nigam, Shubhanchi

AU - Stasiuk, Graeme J.

AU - Prior, Timothy J.

AU - Archibald, Stephen J.

AU - Redshaw, Carl

PY - 2016/1/1

Y1 - 2016/1/1

N2 - A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC50 values in the range 30-170 μM.

AB - A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC50 values in the range 30-170 μM.

UR - http://www.scopus.com/inward/record.url?scp=84976556957&partnerID=8YFLogxK

U2 - 10.1039/c6ce00209a

DO - 10.1039/c6ce00209a

M3 - Article

AN - SCOPUS:84976556957

SN - 1466-8033

VL - 18

SP - 4977

EP - 4987

JO - CRYSTENGCOMM

JF - CRYSTENGCOMM

IS - 26

ER -

Synthesis, structures and cytotoxicity studies of: P -sulfonatocalix[4]arene lanthanide complexes

Abstract

Access to Document

Other files and links

Fingerprint

Cite this