TY - JOUR
T1 - Systematic review of pharmacological treatments for depressive symptoms in Huntington's disease
AU - Moulton, Calum D.
AU - Hopkins, C. W P
AU - Bevan-Jones, W. Richard
PY - 2014
Y1 - 2014
N2 - Background: Depressive symptoms are common in Huntington's disease (HD), profoundly affect quality of life, and predict suicidal ideation. However, no recent review of antidepressant treatment in HD has been published. Methods: We performed a PRISMA systematic review of HD studies, which used a recognized antidepressant and measured change in depressive symptoms using a validated psychiatric scale. Controlled trials, uncontrolled trials, observational studies, and case series were included. Results: Eleven studies were included, totalling 190 patients. One study examined venlafaxine, one fluoxetine, one citalopram, one atomoxetine, one modafinil, one lithium, and five antipsychotics. No studies were of adequate duration, size, or outcome, and no controlled trial in a depressed population produced a positive result. Conclusions: Inadequate evidence exists to guide antidepressant treatment in HD. Further research is needed to assess antidepressant efficacy and to examine whether treatment of depression represents a modifiable target for the high suicide rate in HD.
AB - Background: Depressive symptoms are common in Huntington's disease (HD), profoundly affect quality of life, and predict suicidal ideation. However, no recent review of antidepressant treatment in HD has been published. Methods: We performed a PRISMA systematic review of HD studies, which used a recognized antidepressant and measured change in depressive symptoms using a validated psychiatric scale. Controlled trials, uncontrolled trials, observational studies, and case series were included. Results: Eleven studies were included, totalling 190 patients. One study examined venlafaxine, one fluoxetine, one citalopram, one atomoxetine, one modafinil, one lithium, and five antipsychotics. No studies were of adequate duration, size, or outcome, and no controlled trial in a depressed population produced a positive result. Conclusions: Inadequate evidence exists to guide antidepressant treatment in HD. Further research is needed to assess antidepressant efficacy and to examine whether treatment of depression represents a modifiable target for the high suicide rate in HD.
KW - Antidepressant
KW - Depression
KW - Rating scale
KW - Suicidality
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=84927518627&partnerID=8YFLogxK
U2 - 10.1002/mds.25980
DO - 10.1002/mds.25980
M3 - Article
C2 - 25111961
AN - SCOPUS:84927518627
SN - 0885-3185
VL - 29
SP - 1556
EP - 1561
JO - Movement disorders : official journal of the Movement Disorder Society
JF - Movement disorders : official journal of the Movement Disorder Society
IS - 12
ER -
