Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

European Eye Epidemiology (E3) Consortium; Matthias M. Mauschitz; Pieter W.M. Bonnemaijer; Kersten Diers; Franziska G. Rauscher; Tobias Elze; Christoph Engel; Markus Loeffler; Johanna Maria Colijn; M. Arfan Ikram; Johannes R. Vingerling; Katie M. Williams; Christopher J. Hammond; Catherine Creuzot-Garcher; Alain M. Bron; Rufino Silva; Sandrina Nunes; Cécile Delcourt; Audrey Cougnard-Grégoire; Frank Holz; Caroline Klaver; Monique M.B. Breteler; Robert P.  Finger

doi:10.1016/j.ophtha.2018.03.026

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

European Eye Epidemiology (E3) Consortium, Matthias M. Mauschitz, Pieter W.M. Bonnemaijer, Kersten Diers, Franziska G. Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M. Arfan Ikram, Johannes R. Vingerling, Katie M. Williams, Christopher J. Hammond, Catherine Creuzot-Garcher, Alain M. Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank HolzCaroline Klaver, Monique M.B. Breteler, Robert P. Finger

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Abstract

Purpose
To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population.
Design
Cross-sectional meta-analysis.
Participants
A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods
We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis.
Main Outcome Measures
Determinants of pRNFLT.
Results
Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions
In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

Original language	English
Journal	Ophthalmology
Early online date	30 Apr 2018
DOIs	https://doi.org/10.1016/j.ophtha.2018.03.026
Publication status	E-pub ahead of print - 30 Apr 2018

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10.1016/j.ophtha.2018.03.026

Systemic and ocular determinants_MAUSCHITZ_Accepted15March2018_GREEN AAMAccepted author manuscript, 598 KBLicence: CC BY-NC-ND

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European Eye Epidemiology (E3) Consortium, Mauschitz, M. M., Bonnemaijer, P. W. M., Diers, K., Rauscher, F. G., Elze, T., Engel, C., Loeffler, M., Colijn, J. M., Ikram, M. A., Vingerling, J. R., Williams, K. M., Hammond, C. J., Creuzot-Garcher, C., Bron, A. M., Silva, R., Nunes, S., Delcourt, C., Cougnard-Grégoire, A., ... Finger, R. P. (2018). Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population. Ophthalmology. Advance online publication. https://doi.org/10.1016/j.ophtha.2018.03.026

@article{5f56a03af405458893a58a82d1661986,

title = "Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population",

abstract = "Purpose To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design Cross-sectional meta-analysis. Participants A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures Determinants of pRNFLT. Results Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.",

author = "{European Eye Epidemiology (E3) Consortium} and Mauschitz, {Matthias M.} and Bonnemaijer, {Pieter W.M.} and Kersten Diers and Rauscher, {Franziska G.} and Tobias Elze and Christoph Engel and Markus Loeffler and Colijn, {Johanna Maria} and Ikram, {M. Arfan} and Vingerling, {Johannes R.} and Williams, {Katie M.} and Hammond, {Christopher J.} and Catherine Creuzot-Garcher and Bron, {Alain M.} and Rufino Silva and Sandrina Nunes and C{\'e}cile Delcourt and Audrey Cougnard-Gr{\'e}goire and Frank Holz and Caroline Klaver and Breteler, {Monique M.B.} and Finger, {Robert P.}",

year = "2018",

month = apr,

day = "30",

doi = "10.1016/j.ophtha.2018.03.026",

language = "English",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

}

European Eye Epidemiology (E3) Consortium, Mauschitz, MM, Bonnemaijer, PWM, Diers, K, Rauscher, FG, Elze, T, Engel, C, Loeffler, M, Colijn, JM, Ikram, MA, Vingerling, JR, Williams, KM , Hammond, CJ, Creuzot-Garcher, C, Bron, AM, Silva, R, Nunes, S, Delcourt, C, Cougnard-Grégoire, A, Holz, F, Klaver, C, Breteler, MMB & Finger, RP 2018, 'Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population', Ophthalmology. https://doi.org/10.1016/j.ophtha.2018.03.026

TY - JOUR

T1 - Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

AU - European Eye Epidemiology (E3) Consortium

AU - Mauschitz, Matthias M.

AU - Bonnemaijer, Pieter W.M.

AU - Diers, Kersten

AU - Rauscher, Franziska G.

AU - Elze, Tobias

AU - Engel, Christoph

AU - Loeffler, Markus

AU - Colijn, Johanna Maria

AU - Ikram, M. Arfan

AU - Vingerling, Johannes R.

AU - Williams, Katie M.

AU - Hammond, Christopher J.

AU - Creuzot-Garcher, Catherine

AU - Bron, Alain M.

AU - Silva, Rufino

AU - Nunes, Sandrina

AU - Delcourt, Cécile

AU - Cougnard-Grégoire, Audrey

AU - Holz, Frank

AU - Klaver, Caroline

AU - Breteler, Monique M.B.

AU - Finger, Robert P.

PY - 2018/4/30

Y1 - 2018/4/30

N2 - Purpose To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design Cross-sectional meta-analysis. Participants A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures Determinants of pRNFLT. Results Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

AB - Purpose To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design Cross-sectional meta-analysis. Participants A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures Determinants of pRNFLT. Results Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

U2 - 10.1016/j.ophtha.2018.03.026

DO - 10.1016/j.ophtha.2018.03.026

M3 - Article

SN - 0161-6420

JO - Ophthalmology

JF - Ophthalmology

ER -

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

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