Systems approach to the study of brain damage in the very preterm newborn

Alan Leviton, Pierre Gressens, Olaf Wolkenhauer, Olaf Dammann

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)
164 Downloads (Pure)

Abstract

Background: A systems approach to the study of brain damage in very preterm newborns has been lacking.

Methods: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and interrelatedness of brain-damaging molecular processes that can be initiated inflammatory phenomena.

Results: Using three transcription factors, nuclear factor-kappa B (NF-κB), Notch-1, and nuclear factor erythroid 2 related factor 2 (NRF2), we show the inter-connectedness of signaling pathways activated by some antecedents of encephalopathy of prematurity.

Conclusions: We hope that as biomarkers of exposures and processes leading to brain damage in the most immature newborns become more readily available, those who apply a systems approach to the study of neuroscience can be persuaded to study the pathogenesis of brain disorders in the very preterm newborn.

Original languageEnglish
Pages (from-to)58
JournalFrontiers in systems neuroscience
Volume9
DOIs
Publication statusPublished - 2015

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