Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

TY - JOUR

T1 - Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

AU - Langley, Sarah R

AU - Bottolo, Leonardo

AU - Kunes, Jaroslav

AU - Zicha, Josef

AU - Zidek, Vaclav

AU - Hubner, Norbert

AU - Cook, Stuart A

AU - Pravenec, Michal

AU - Aitman, Timothy J

AU - Petretto, Enrico

PY - 2013/3/15

Y1 - 2013/3/15

N2 - Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause disease remain mostly unclear. Here, we used comparative genomics between human and an established rat model of hypertension to explore the transcriptional mechanisms mediating the effect of genes identified in 15 hypertension GWAS.

AB - Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause disease remain mostly unclear. Here, we used comparative genomics between human and an established rat model of hypertension to explore the transcriptional mechanisms mediating the effect of genes identified in 15 hypertension GWAS.

KW - Animals

KW - Blood Pressure

KW - Gene Expression Regulation

KW - Genome-Wide Association Study

KW - Humans

KW - Hypertension

KW - Male

KW - Quantitative Trait Loci

KW - Rats

KW - Rats, Inbred BN

KW - Rats, Inbred SHR

U2 - 10.1093/cvr/cvs329

DO - 10.1093/cvr/cvs329

M3 - Article

C2 - 23118132

SN - 0008-6363

VL - 97

SP - 653

EP - 665

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 4

ER -