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T cell metabolism in chronic viral infection

Research output: Contribution to journalReview article

L. J. Pallett, N. Schmidt, A. Schurich

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalClinical & Experimental Immunology
Volume197
Issue number2
Early online date30 Apr 2019
DOIs
Publication statusPublished - 1 Aug 2019

King's Authors

Abstract

T cells are a fundamental component of the adaptive immune response in the context of both acute and chronic viral infection. Tight control over the metabolic processes within T cells provides an additional level of immune regulation that is interlinked with nutrient sensing and the continued balancing of co-stimulatory and co-inhibitory signals. Under-pinning T cell responsiveness for viral control are a number of phenotypic and functional adaptations ensuring adequate nutrient uptake and their utilization. T cells responding to persistent viral infections often exhibit a profile associated with immune cell exhaustion and a dysregulated meta-bolic profile, driven by a combination of chronic antigenic stimulation and signals from the local microenvironment. Understanding alterations in these metabolic processes provides an important basis for immuno-therapeutic strategies to treat persistent infections

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