T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy

J N Francis; C M Lloyd; I Sabroe; S R Durham; S J Till

doi:10.1111/j.1398-9995.2006.01253.x

T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy

J N Francis, C M Lloyd, I Sabroe, S R Durham, S J Till

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

In T cell-associated allergic inflammation, homing of T-helper 2 (Th2) effector cells to mucosal sites may be influenced by chemokine receptor expression. Previous studies have identified CCR3 and CCR4 as putative markers of Th2 cells and CCR5 and CXCR3 as markers of Th1 cells. The aim of this study was to assess differential chemokine receptor expression from symptomatic atopic grass pollen-sensitive subjects, compared with patients on high-dose allergen injection immunotherapy (IT) and healthy controls.

Original language	English
Pages (from-to)	59-65
Number of pages	7
Journal	Allergy
Volume	62
Issue number	1
DOIs	https://doi.org/10.1111/j.1398-9995.2006.01253.x
Publication status	Published - Jan 2007

Keywords

Cell Count
Humans
Leukocytes
Desensitization, Immunologic
Receptors, CCR3
Th2 Cells
Receptors, Chemokine
Rhinitis, Allergic, Perennial
Cells, Cultured
Rhinitis, Allergic, Seasonal
Poaceae
Adult
Interleukin-5
Middle Aged
Female
Male
T-Lymphocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1398-9995.2006.01253.x

Cite this

@article{ad720ab2e2544bac8a07111f2f845d94,

title = "T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy",

abstract = "In T cell-associated allergic inflammation, homing of T-helper 2 (Th2) effector cells to mucosal sites may be influenced by chemokine receptor expression. Previous studies have identified CCR3 and CCR4 as putative markers of Th2 cells and CCR5 and CXCR3 as markers of Th1 cells. The aim of this study was to assess differential chemokine receptor expression from symptomatic atopic grass pollen-sensitive subjects, compared with patients on high-dose allergen injection immunotherapy (IT) and healthy controls.",

keywords = "Cell Count, Humans, Leukocytes, Desensitization, Immunologic, Receptors, CCR3, Th2 Cells, Receptors, Chemokine, Rhinitis, Allergic, Perennial, Cells, Cultured, Rhinitis, Allergic, Seasonal, Poaceae, Adult, Interleukin-5, Middle Aged, Female, Male, T-Lymphocytes",

author = "Francis, {J N} and Lloyd, {C M} and I Sabroe and Durham, {S R} and Till, {S J}",

year = "2007",

month = jan,

doi = "10.1111/j.1398-9995.2006.01253.x",

language = "English",

volume = "62",

pages = "59--65",

journal = "Allergy",

issn = "0105-4538",

publisher = "Blackwell Publishing",

number = "1",

}

TY - JOUR

T1 - T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy

AU - Francis, J N

AU - Lloyd, C M

AU - Sabroe, I

AU - Durham, S R

AU - Till, S J

PY - 2007/1

Y1 - 2007/1

N2 - In T cell-associated allergic inflammation, homing of T-helper 2 (Th2) effector cells to mucosal sites may be influenced by chemokine receptor expression. Previous studies have identified CCR3 and CCR4 as putative markers of Th2 cells and CCR5 and CXCR3 as markers of Th1 cells. The aim of this study was to assess differential chemokine receptor expression from symptomatic atopic grass pollen-sensitive subjects, compared with patients on high-dose allergen injection immunotherapy (IT) and healthy controls.

AB - In T cell-associated allergic inflammation, homing of T-helper 2 (Th2) effector cells to mucosal sites may be influenced by chemokine receptor expression. Previous studies have identified CCR3 and CCR4 as putative markers of Th2 cells and CCR5 and CXCR3 as markers of Th1 cells. The aim of this study was to assess differential chemokine receptor expression from symptomatic atopic grass pollen-sensitive subjects, compared with patients on high-dose allergen injection immunotherapy (IT) and healthy controls.

KW - Cell Count

KW - Humans

KW - Leukocytes

KW - Desensitization, Immunologic

KW - Receptors, CCR3

KW - Th2 Cells

KW - Receptors, Chemokine

KW - Rhinitis, Allergic, Perennial

KW - Cells, Cultured

KW - Rhinitis, Allergic, Seasonal

KW - Poaceae

KW - Adult

KW - Interleukin-5

KW - Middle Aged

KW - Female

KW - Male

KW - T-Lymphocytes

U2 - 10.1111/j.1398-9995.2006.01253.x

DO - 10.1111/j.1398-9995.2006.01253.x

M3 - Article

C2 - 17156343

SN - 0105-4538

VL - 62

SP - 59

EP - 65

JO - Allergy

JF - Allergy

IS - 1

ER -

T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this