Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients

Ian Smith; Bronwyn L. Pearse; Daniel J. Faulke; Rishen Naidoo; Lisa Nicotra; Peter Hopkins; Elizabeth G. Ryan

doi:10.1053/j.jvca.2016.06.027

Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients

Ian Smith^*, Bronwyn L. Pearse, Daniel J. Faulke, Rishen Naidoo, Lisa Nicotra, Peter Hopkins, Elizabeth G. Ryan

^*Corresponding author for this work

Biostatistics & Health Informatics

Prince Charles Hospital Brisbane

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Objective: Lung transplantation is associated with high rates of bleeding and frequent blood transfusion. The authors aimed to determine if point-of-care coagulation testing (POCCT) reduced transfusion requirements. Design, Settings, and Participants: A before-and-after cohort analysis conducted at a single tertiary referral center. Ninety-three sequential adult patients between January 2010 and January 2014 undergoing isolated lung transplant without preoperative extracorporeal support were analyzed. Intervention: ROTEM and multi-plate POCCT were introduced on July 1, 2012, with an associated algorithm based on the results. Measurements and Main Results: Statistically significant decreases in the proportion of patients receiving PRBCs (87% . v 65%; p = 0.015), FFP (72% . v 30%; p

Original language	English
Journal	Journal of Cardiothoracic and Vascular Anesthesia
DOIs	https://doi.org/10.1053/j.jvca.2016.06.027
Publication status	Accepted/In press - 2016

Keywords

Blood transfusion
Lung transplantation
Point-of-care coagulation testing

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10.1053/j.jvca.2016.06.027

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title = "Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients",

abstract = "Objective: Lung transplantation is associated with high rates of bleeding and frequent blood transfusion. The authors aimed to determine if point-of-care coagulation testing (POCCT) reduced transfusion requirements. Design, Settings, and Participants: A before-and-after cohort analysis conducted at a single tertiary referral center. Ninety-three sequential adult patients between January 2010 and January 2014 undergoing isolated lung transplant without preoperative extracorporeal support were analyzed. Intervention: ROTEM and multi-plate POCCT were introduced on July 1, 2012, with an associated algorithm based on the results. Measurements and Main Results: Statistically significant decreases in the proportion of patients receiving PRBCs (87% . v 65%; p = 0.015), FFP (72% . v 30%; p",

keywords = "Blood transfusion, Lung transplantation, Point-of-care coagulation testing",

author = "Ian Smith and Pearse, {Bronwyn L.} and Faulke, {Daniel J.} and Rishen Naidoo and Lisa Nicotra and Peter Hopkins and Ryan, {Elizabeth G.}",

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doi = "10.1053/j.jvca.2016.06.027",

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T1 - Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients

AU - Smith, Ian

AU - Pearse, Bronwyn L.

AU - Faulke, Daniel J.

AU - Naidoo, Rishen

AU - Nicotra, Lisa

AU - Hopkins, Peter

AU - Ryan, Elizabeth G.

PY - 2016

Y1 - 2016

N2 - Objective: Lung transplantation is associated with high rates of bleeding and frequent blood transfusion. The authors aimed to determine if point-of-care coagulation testing (POCCT) reduced transfusion requirements. Design, Settings, and Participants: A before-and-after cohort analysis conducted at a single tertiary referral center. Ninety-three sequential adult patients between January 2010 and January 2014 undergoing isolated lung transplant without preoperative extracorporeal support were analyzed. Intervention: ROTEM and multi-plate POCCT were introduced on July 1, 2012, with an associated algorithm based on the results. Measurements and Main Results: Statistically significant decreases in the proportion of patients receiving PRBCs (87% . v 65%; p = 0.015), FFP (72% . v 30%; p

AB - Objective: Lung transplantation is associated with high rates of bleeding and frequent blood transfusion. The authors aimed to determine if point-of-care coagulation testing (POCCT) reduced transfusion requirements. Design, Settings, and Participants: A before-and-after cohort analysis conducted at a single tertiary referral center. Ninety-three sequential adult patients between January 2010 and January 2014 undergoing isolated lung transplant without preoperative extracorporeal support were analyzed. Intervention: ROTEM and multi-plate POCCT were introduced on July 1, 2012, with an associated algorithm based on the results. Measurements and Main Results: Statistically significant decreases in the proportion of patients receiving PRBCs (87% . v 65%; p = 0.015), FFP (72% . v 30%; p

KW - Blood transfusion

KW - Lung transplantation

KW - Point-of-care coagulation testing

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DO - 10.1053/j.jvca.2016.06.027

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SN - 1053-0770

JO - Journal of Cardiothoracic and Vascular Anesthesia

JF - Journal of Cardiothoracic and Vascular Anesthesia

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Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients

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Keywords

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