Targeted lipid-polyaniline hybrid nanoparticles for photoacoustic imaging guided photothermal therapy of cancer

TY - JOUR

T1 - Targeted lipid-polyaniline hybrid nanoparticles for photoacoustic imaging guided photothermal therapy of cancer

AU - Wang, Jinping

AU - Yan, Ran

AU - Guo, Fang

AU - Yu, Meng

AU - Tan, Fengping

AU - Li, Nan

PY - 2016

Y1 - 2016

N2 - Designing a targeted and versatile photothermal agent for the integration of precise diagnosis and effective photothermal treatment of tumors is desirable but remains a great challenge. In this study, folic acid ligand conjugated lipid-coated polyaniline hybrid nanoparticles (FA-Lipid-PANI NPs) were successfully fabricated by a distinctive technology. The obtained hybrid FA-Lipid-PANI NPs with small size exhibited not only significant photoacoustic (PA) imaging signals, but also a remarkable photothermal effect for tumor treatment. With PA imaging and photothermal therapy (PTT), the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of FA-Lipid-PANI NPs. These multifunctional nanoparticles could play an important role in simultaneously facilitating imaging and PTT to achieve better therapeutic efficacy.

AB - Designing a targeted and versatile photothermal agent for the integration of precise diagnosis and effective photothermal treatment of tumors is desirable but remains a great challenge. In this study, folic acid ligand conjugated lipid-coated polyaniline hybrid nanoparticles (FA-Lipid-PANI NPs) were successfully fabricated by a distinctive technology. The obtained hybrid FA-Lipid-PANI NPs with small size exhibited not only significant photoacoustic (PA) imaging signals, but also a remarkable photothermal effect for tumor treatment. With PA imaging and photothermal therapy (PTT), the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of FA-Lipid-PANI NPs. These multifunctional nanoparticles could play an important role in simultaneously facilitating imaging and PTT to achieve better therapeutic efficacy.

KW - hybrid nanoparticles

KW - near-infrared light

KW - phospholipids

KW - photoacoustic imaging

KW - polyaniline

KW - Targeted photothermal therapy

UR - http://www.scopus.com/inward/record.url?scp=84975092174&partnerID=8YFLogxK

U2 - 10.1088/0957-4484/27/28/285102

DO - 10.1088/0957-4484/27/28/285102

M3 - Article

AN - SCOPUS:84975092174

SN - 0957-4484

VL - 27

JO - NANOTECHNOLOGY

JF - NANOTECHNOLOGY

IS - 28

M1 - 285102

ER -