Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease

TY - JOUR

T1 - Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal disease

AU - Krimholtz, M J

AU - Karalliedde, J

AU - Thomas, S

AU - Bilous, R

AU - Viberti, G

PY - 2005

Y1 - 2005

N2 - Combination of an angiotensin-converting enzyme inhibitor (ACEI) with an angiotensin 11 receptor blocker is advocated as a treatment option in diabetic patients with nephropathy and residual albuminuria while on antihypertensive therapy. Abrogation of albuminuria is a key treatment goal to prevent disease progression. The assumption is that albuminuria reduction is the result of more complete blockade of the renin angiotensin system; thus, the ACEI-angiotensin 11 receptor blocker combination would have a greater albuminuria-lowering effect than the combination of an ACEI with a calcium channel blocker such as amlodipine, which causes similar reductions in BP but does not affect the renin angiotensin system. Twenty-eight patients who had type 1 diabetes and known diabetic renal disease and had a persistently elevated albumin creatinine ratio (ACR) >10 mg/mmol despite office BP recordings

AB - Combination of an angiotensin-converting enzyme inhibitor (ACEI) with an angiotensin 11 receptor blocker is advocated as a treatment option in diabetic patients with nephropathy and residual albuminuria while on antihypertensive therapy. Abrogation of albuminuria is a key treatment goal to prevent disease progression. The assumption is that albuminuria reduction is the result of more complete blockade of the renin angiotensin system; thus, the ACEI-angiotensin 11 receptor blocker combination would have a greater albuminuria-lowering effect than the combination of an ACEI with a calcium channel blocker such as amlodipine, which causes similar reductions in BP but does not affect the renin angiotensin system. Twenty-eight patients who had type 1 diabetes and known diabetic renal disease and had a persistently elevated albumin creatinine ratio (ACR) >10 mg/mmol despite office BP recordings

U2 - 10.1681/ASN.2004110973

DO - 10.1681/ASN.2004110973

M3 - Article

SN - 1555-905X

VL - 16

SP - S42 - S47

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

IS - 3 SUPPL. 1

ER -