Targeting bacterial degradation machinery as an antibacterial strategy

Radoslav Petkov; Amy h. Camp; Rivka l. Isaacson; James h. Torpey

doi:10.1042/BCJ20230191

Targeting bacterial degradation machinery as an antibacterial strategy

Radoslav Petkov, Amy h. Camp, Rivka l. Isaacson, James h. Torpey

Chemistry

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacPROTACs to trigger the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance.

Original language	English
Pages (from-to)	1719-1731
Number of pages	13
Journal	Biochemical Journal
Volume	480
Issue number	21
Early online date	2 Nov 2023
DOIs	https://doi.org/10.1042/BCJ20230191
Publication status	Published - 15 Nov 2023

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10.1042/BCJ20230191Licence: CC BY

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title = "Targeting bacterial degradation machinery as an antibacterial strategy",

abstract = "The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacPROTACs to trigger the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance.",

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AU - Petkov, Radoslav

AU - Camp, Amy h.

AU - Isaacson, Rivka l.

AU - Torpey, James h.

PY - 2023/11/15

Y1 - 2023/11/15

N2 - The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacPROTACs to trigger the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance.

AB - The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacPROTACs to trigger the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance.

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U2 - 10.1042/BCJ20230191

DO - 10.1042/BCJ20230191

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EP - 1731

JO - Biochemical Journal

JF - Biochemical Journal

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ER -

Targeting bacterial degradation machinery as an antibacterial strategy

Abstract

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