Targeting bacterial degradation machinery as an antibacterial strategy

Radoslav Petkov, Amy h. Camp, Rivka l. Isaacson, James h. Torpey

Research output: Contribution to journalReview articlepeer-review

Abstract

The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacPROTACs to trigger the degradation of specific proteins of interest through the hijacking of the ClpCP machinery. These strategies represent an important emerging avenue for combatting antimicrobial resistance.
Original languageEnglish
Pages (from-to)1719-1731
Number of pages13
JournalBiochemical Journal
Volume480
Issue number21
Early online date2 Nov 2023
DOIs
Publication statusPublished - 15 Nov 2023

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